Research Scientist I - Cardiovascular Disease Initiative
- The Broad Institute, Inc.
- Cambridge, Massachusetts
- Full Time
Research Scientist I - Cardiovascular Disease Initiative
General information
Location
Cambridge, MA
Ref #
42376
Job Family
Research
Date published
29-May-2025
Time Type
Full time
Description & Requirements
The Broad Institute of MIT & Harvard, a world leader in genetic research, is looking for an exceptional candidate to join the Cardiovascular Disease Initiative (CVDi) led by Dr. Patrick Ellinor. The successful candidate will join an interdisciplinary team of computational biologists, laboratory scientists, industry collaborators, and clinicians and will work closely with other Research Scientists.
The team works together to identify and validate new genes associated with various cardiovascular diseases. The candidate will work as a member of the Cardiovascular Disease Initiative and will conduct experimental research studies at the bench, supervise a research associate, and lead therapeutics project(s) targeting cardiovascular disease.
Example workstreams for projects include: validating genes and proteins of interest using various in vitro techniques, developing and validating in vitro disease models, assessing suitability of genes for assay development, carrying out in vitro experiments to understand the biology behind target gene functions.
Key responsibilities
Design and execute research plans to ensure that critical project requirements, timelines and deliverables are met with minimal guidance from Senior Research Scientist.
Develop and execute cell-based assays to support target validation and hit identification & optimization
Contribute to target validation using genomic perturbation techniques such as CRISPR, siRNA, etc.
Troubleshoot scientific problems with minimal guidance
Analyze experimental data and communicate scientific results to team members
Supervise and mentor Research Associate(s) and junior team members
Contribute to various research projects in a collaborative manner
Requirements
Ph.D. in Biology (Developmental, Molecular, Cellular Biology), Biochemistry, or related life science field with 0-3 years experience in an industrial or academic setting with a proven record of successful interaction with external collaborators and team members
Hands-on experience in cellular assay development and proficiency with standard assay formats (e.g. imaging, luminescence-/fluorescence-based cellular readouts, immunohistochemistry, Western blotting) in primary and cultured cells
Experience with induced pluripotent stem cell (iPSC) culture and cardiomyocyte differentiation is preferred
Experience with cardiomyocyte-based assays such as calcium imaging, contractility and in vitro modeling of cardiac disease is preferred
Proficient with standard cellular and molecular biology techniques such as qPCR, western blot, siRNA transfection, viral transduction, etc.
Proficiency with tissue and cell based imaging techniques, e.g. tissue sectioning, staining, histology, confocal microscopy, in situ hybridization is a plus
Experience with CRISPR targeting technologies in primary cells
Strong understanding of cardiac biology and disease
Ability to develop research plans for executing strategy, operate and maintain equipment, and perform laboratory work, with complete independence
Track record of working on complex problems, and ability to integrate data from multiple disciplines
Supervising skills are a plus
Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
Outstanding verbal and written communication abilities
Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
A passion and curiosity for science and sense of urgency to find new medicines to benefit patients
The successful candidate will be a results-focused, team-oriented, creative, bench scientist, able to excel in a fast-track environment. The candidate must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management, for identifying and achieving research goals. The diverse expertise of the Broad CVDi platform fosters further opportunities for the successful candidate to engage in broad activities.
General information
Location
Cambridge, MA
Ref #
42376
Job Family
Research
Date published
29-May-2025
Time Type
Full time
Description & Requirements
The Broad Institute of MIT & Harvard, a world leader in genetic research, is looking for an exceptional candidate to join the Cardiovascular Disease Initiative (CVDi) led by Dr. Patrick Ellinor. The successful candidate will join an interdisciplinary team of computational biologists, laboratory scientists, industry collaborators, and clinicians and will work closely with other Research Scientists.
The team works together to identify and validate new genes associated with various cardiovascular diseases. The candidate will work as a member of the Cardiovascular Disease Initiative and will conduct experimental research studies at the bench, supervise a research associate, and lead therapeutics project(s) targeting cardiovascular disease.
Example workstreams for projects include: validating genes and proteins of interest using various in vitro techniques, developing and validating in vitro disease models, assessing suitability of genes for assay development, carrying out in vitro experiments to understand the biology behind target gene functions.
Key responsibilities
Design and execute research plans to ensure that critical project requirements, timelines and deliverables are met with minimal guidance from Senior Research Scientist.
Develop and execute cell-based assays to support target validation and hit identification & optimization
Contribute to target validation using genomic perturbation techniques such as CRISPR, siRNA, etc.
Troubleshoot scientific problems with minimal guidance
Analyze experimental data and communicate scientific results to team members
Supervise and mentor Research Associate(s) and junior team members
Contribute to various research projects in a collaborative manner
Requirements
Ph.D. in Biology (Developmental, Molecular, Cellular Biology), Biochemistry, or related life science field with 0-3 years experience in an industrial or academic setting with a proven record of successful interaction with external collaborators and team members
Hands-on experience in cellular assay development and proficiency with standard assay formats (e.g. imaging, luminescence-/fluorescence-based cellular readouts, immunohistochemistry, Western blotting) in primary and cultured cells
Experience with induced pluripotent stem cell (iPSC) culture and cardiomyocyte differentiation is preferred
Experience with cardiomyocyte-based assays such as calcium imaging, contractility and in vitro modeling of cardiac disease is preferred
Proficient with standard cellular and molecular biology techniques such as qPCR, western blot, siRNA transfection, viral transduction, etc.
Proficiency with tissue and cell based imaging techniques, e.g. tissue sectioning, staining, histology, confocal microscopy, in situ hybridization is a plus
Experience with CRISPR targeting technologies in primary cells
Strong understanding of cardiac biology and disease
Ability to develop research plans for executing strategy, operate and maintain equipment, and perform laboratory work, with complete independence
Track record of working on complex problems, and ability to integrate data from multiple disciplines
Supervising skills are a plus
Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts
Outstanding verbal and written communication abilities
Ability to adapt to and effectively manage changes in a fast paced and dynamic environment
A passion and curiosity for science and sense of urgency to find new medicines to benefit patients
The successful candidate will be a results-focused, team-oriented, creative, bench scientist, able to excel in a fast-track environment. The candidate must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management, for identifying and achieving research goals. The diverse expertise of the Broad CVDi platform fosters further opportunities for the successful candidate to engage in broad activities.
Job ID: 479417689
Originally Posted on: 6/2/2025
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