Senior Scientist II, Structural and Biophysical Analytics

Job Description Summary

The Structural BioAnalytics (SBA) group within Global Discovery Chemistry at Novartis Biomedical Research in Emeryville, CA (San Francisco Bay Area) is seeking a self-motivated, highly skilled scientist with extensive experience in structural biology analytical techniques. Candidates with a strong background in one or more of the following technologies are strongly encouraged to apply: protein mass spectrometry (MS) techniques such as hydrogen-deuterium exchange MS (HDX-MS), native MS (nMS), hydroxyl radical protein footprinting (HRPF) or Biomolecular NMR (Bio-NMR). We expect the successful candidate to be curious about new drug discovery approaches, eager to learn and to adapt quickly to the evolving needs and priorities of the SBA group. While solid hands-on experience of LC-MS, HPLC/UHPLC is preferred, we invest in our employees growth and offer various professional development opportunities including technical training and mentorship programs. Knowledge of other biochemical, biophysical and cellular screening techniques for small molecule characterization and development is a plus.

Job Description

Internal Job Title : Senior Scientist II

Position Location: Emeryville, CA onsite #LI-onsite

About the Role:

The Structural BioAnalytics (SBA) group within Global Discovery Chemistry at Novartis Biomedical Research in Emeryville, CA (San Francisco Bay Area) is seeking a self-motivated, highly skilled scientist with extensive experience in structural biology analytical techniques. Candidates with a strong background in one or more of the following technologies are strongly encouraged to apply: protein mass spectrometry (MS) techniques such as hydrogen-deuterium exchange MS (HDX-MS), native MS (nMS), hydroxyl radical protein footprinting (HRPF) or Biomolecular NMR (Bio-NMR). We expect the successful candidate to be curious about new drug discovery approaches, eager to learn and to adapt quickly to the evolving needs and priorities of the SBA group. While solid hands-on experience of LC-MS, HPLC/UHPLC is preferred, we invest in our employees growth and offer various professional development opportunities including technical training and mentorship programs. Knowledge of other biochemical, biophysical and cellular screening techniques for small molecule characterization and development is a plus.

SBA is a multidisciplinary team with expertise in biomolecular nuclear magnetic resonance (Bio-NMR), small molecule NMR, nMS and HDX-MS. Our group collaborates closely with other structural and biophysical groups across Novartis to investigate new drug targets and identify and validate small molecule compounds from biochemical, biophysical and cellular screens. Together we collaborate with scientists at the frontiers of chemical biology, chemical genomics, data sciences and disease biology to identify opportunities for next generation therapeutics. Our goal is to find and develop small or large molecules with the potential for modulating diseases, and we support or lead drug discovery projects in various therapeutic areas like oncology, immuno-oncology, virology, parasitical, cardiovascular, immunological and neurological diseases.

The Senior Scientist II will be an integral member of structure-based drug discovery teams. They will provide structural MS and/or NMR expertise to advance early drug discovery efforts, design and conduct HDX-MS, native MS and/or Bio-NMR experiments to solve key scientific questions, communicate effectively and efficiently in team meetings, review sessions, and collaboratively work with other scientists to develop innovative medicines. This role will impact our local discovery efforts and the global discovery portfolio through bench-level and strategic contributions. The successful candidate will be expected to implement novel structural MS and/or Bio-NMR techniques to answer drug discovery questions related to protein dynamics/folding, mutant analysis, epitope/paratope mapping, and protein/nucleic acid-small molecule interactions.

Key Responsibilities:

• Interpret data, present results and provide strategic input to internal project teams and global stakeholders to help drive our drug discovery projects

• Prepare HDX-MS samples as well as record and analyze deuterium labeling data of proteins in complex with peptides, nucleic acids or small molecules

• Prepare, execute and analyze native MS experiments

• Design, execute and interpret Biomolecular NMR experiments

• Independently support multiple drug discovery projects in parallel

• Working closely with scientists in Protein Sciences to creatively design and generate protein constructs suitable for nMS, HDX-MS or Bio-NMR experiments

• Participate in maintaining our HDX-MS automation platform with associated computing and robotics

• Work with in-house structural biology and drug discovery databases

• Share lab and office tasks, such as ordering reagents, organizing inventories and keeping experimental records, with other team members

• Contribute intellectually to structure-based drug discovery projects and collaborate with partners from other disciplines like disease biology, biochemistry, chemistry, bioinformatics, CADD and IT

Minimum requirements:

• A degree in Biophysics, Chemistry, Biochemistry or related field. B.S. with at least 8 yrs, M.S with at least 5 years or Ph.D. with relevant experience in either an academic or industrial setting

• Solid background in one or more of the following techniques: analytical chemistry, mass spectrometry, Biomolecular NMR, protein biochemistry, or separation science as demonstrated by authored publications in peer-reviewed journals

• Hands-on experience working with viral-fusion and membrane bound proteins

• Successfully demonstrated initiative, teamwork, collaboration and can-do attitude

• Flexibility to accommodate to rapidly changing priorities and deadlines, with strong interpersonal, written & oral communication and problem-solving skills

Desired Skills:

• Hands-on experience with the operation and troubleshooting of mass spectrometers used for structural MS and associated equipment, in addition to experience with Trajan HDX automation platforms are a plus

• Protein design, expression and purification knowledge as well as conceptual familiarity with one or more structural biology techniques such as, XRC, cEM, SPR, DSF, ITC are a plus

• Familiarity with mass spectrometry peptide mapping techniques like Top N and Data-Independent Acquisition (DIA) workflows are a plus

• Knowledge of R and python for MS data analysis is a bonus

The salary for this position is expected to range between $93,800 and $174,200 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +... and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$93,800.00 - $174,200.00

Skills Desired

Analysis, Analysis, Analytical Chemistry, Analytical Skill, Automated Process, Chemical Analysis, Chemical Laboratory, Chemical Synthesis, Chemistry, Data Analytics, Data Science, Diversity & Inclusion, Drug Development, Drug Discovery, HPLC (High-Performance Liquid Chromatography), Innovation, Innovative Medicines, Medical Research, Molecular Biology, Organic Chemistry, Pharmaceutical Chemistry, Pharmaceutical Industry, Physics, Process Simulation, R&D (Research And Development) {+ 3 more}