Job Description As a Senior Scientist, you will be responsible for leading and overseeing multiple client projects concurrently. You will design, plan, and execute experimental protocols using shake-flasks, high-throughput bioreactor systems (ambr15/ambr250), and bench-top small-scale bioreactors to optimize upstream cell culture process performance for manufacturing various biologics, including monoclonal antibodies and therapeutic recombinant proteins. You will independently optimize and develop robust and scalable bioprocess platforms, primarily fed-batch and perfusion systems. This role involves driving innovation by scouting, assessing, developing, and implementing new technology platforms such as PAT, process control, culture media, and feed media optimization. Responsibilities
- Lead and oversee multiple client projects in parallel.
- Design, plan, and execute experimental protocols using shake-flasks, high-throughput bioreactor systems, and small-scale bioreactors.
- Optimize upstream cell culture process performance for manufacturing biologics.
- Develop robust and scalable bioprocess platforms, primarily fed-batch and perfusion systems.
- Drive innovation by implementing new technology platforms.
- Support additional R&D Services teams by generating, reviewing, and interpreting USP results.
- Leverage cell culture expertise to support investigations and troubleshoot complex technical challenges.
- Ph.D. in Bioprocess or Biochemical Engineering with at least 7 years of relevant experience, including more than 3 years of USP industrial experience, or M.Sc. with at least 10 years of relevant experience, including more than 2 years of USP industrial experience.
- Proven track record and expertise in high throughput process characterization and optimization techniques and tools such as DoE, statistical analysis, and QbD.
- Expertise in developing, optimizing, and scaling up Continuous Perfusion and Fed-batch systems.
- Proficient in upstream process scale-up and scale-down to support commercialization.
- Proficient in designing and operating high throughput experiments using Amber15/Amber250.
- Strong written and oral communication skills.
- Ability to read, analyze, and interpret scientific and technical journals, financial reports, and legal documents.
- Proficient in technical writing and verbal communication to present updates to various stakeholders.
- Ability to define problems, collect data, establish facts, and draw valid conclusions.
- Good working knowledge of regulatory agencies and guidance documents governing GMP manufacturing such as ICH, FDA, and EMA.
- CDMO experience within bioprocess development is highly preferred.
Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.
The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.
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