Scientist, Upstream Process

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking a Scientist, Upstream Process as part of the Vector Biology team based in Philadelphia, PA.

Role Overview

This role supports upstream lentiviral vector production using suspension cell cultures, including shake flask and bioreactor systems up to 40L, with a focus on process optimization through Design of Experiments. The position also assists in downstream workflows such as cell clarification, ion exchange purification, and analytical assays while working both independently and collaboratively with cross functional teams.

Key Responsibilities

• Lentiviral vector (LVV) production using suspension cells

• Upstream LVV production with shake flask at scale (>2L production)

• Optimize upstream process based on Design Of Experiemnts

• Develop upstream scale-up process using single use bioreactor up to 40L

• Supports LVV production for internal research teams

• Cell clarification method development including depth filtration or continuous centrifugation

• Help downstream production and analytical assays including cell clarification using depth filters, IEX and titration assay

• Independently perform daily tasks and closely working with other functional members.

Requirements

• BS degree with 3+ years; MS degree with 1+ years; PhD in molecular & cellular biology, chemical engineering, biomedical engineering or related field.

• Experience in viral vector productions using suspension cell lines

• Experience in bioreactor

• Strong knowledge & experience in LVV technology

• Perfusion and cell clarification method experience

• Ability to think strategically, balance short-term goals and maintain flexibility is preferred.

• Experience in vector core or CDMO is a plus.

• Comfortable in a fast-paced biotech environment and able to adjust workload based upon priorities

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The anticipated base pay range for this is: $93,463 - $128,512 USD.

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.