Analytical Method Automation Sr. Associate Scientist

Description:

• We are seeking an Analytical Method Automation Sr. Associate Scientist to contribute to the development and implementation of novel immunoassays that enable rapid, unsupervised and robust characterization of cell therapy process intermediates during the manufacturing process.

• This candidate will work closely with lab automation engineers, analytical development and process development scientists to test and implement novel reagents to streamline sample preparation, data acquisition and data analysis workflow.

• The candidate will also work with the team to transition from manual to automated workflows as development progresses, characterizing method performance and robustness between the two modes.

• This candidate will support the qualification of the developed automated assay, ensuring method readiness for manufacturing implementation.

• This role provides a unique opportunity to screen and implement novel assay technologies to support near real-time CAR-T monitoring during manufacturing.

• Analytical Method Development:

  • Test commercially available reagents for assessment in novel flow cytometry methods.

  • Plan method testing to support thorough screening of sample preparation parameters and their impact on data acquisition/analysis quality

  • Support custom reagent testing and streamlining of analytical method to enable operator-free execution

  • Execute analytical method qualification studies to demonstrate readiness for manufacturing implementation

• Data Analysis and Reporting

  • Analyze experiment data to identify trends, support decision making and determine next steps

  • Prepare and present data on development progress, analytical method performance across sample types, comparability to existing methods where applicable

  • Author technical documents such as method operating procedures, comparability and qualification protocols and reports.

  • Collaboration and Communication:

  • Communicate effectively with internal stakeholders to ensure alignment and transparency.

  • Work with internal collaborators to support method transfer to other sites

Qualifications:

• Bachelor's degree in molecular or cellular biology, biomedical engineering, or related discipline

• A strong background in immunoassays, particularly flow cytometry development, will be needed .

• 4-5 years of experience in cell-based assay development, specifically cell counting and flow-based assays

• Previous experience with flow cytometry assay development for cell characterization, including panel design and sample preparation protocol development

• Experience with method development and qualification

• Knowledge of flow cytometry reagents and approaches to support automation and streamlining of methods

• Previous experience with in vitro culture of primary cells

• Highly motivated, detail oriented with the ability to multi-task

• Ability to work independently and as part of a team

• Strong organizational and time management skills

• Strong written, verbal and presentation skills

• Strong assay development skills (particularly for flow cytometry), flow cytometry panel design, Human T cell characterization experience.

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance : Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.