Postdoctoral Fellow - Thoracic Head & Neck Medical Oncology (Tina Cascone's Lab)

The University of Texas MD Anderson Cancer Center
Houston, Texas
Full Time

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The Cascone Lab at the world-renowned University of Texas MD Anderson Cancer Center is seeking one or more highly motivated and ambitious postdoctoral fellows to join a well-funded, dynamic, and question-driven research program focused on advancing the science of lung cancer immunology and immunotherapy.

Under the mentorship of Tina Cascone, M.D., Ph.D., a physician-scientist and Associate Professor with tenure, and Director of Translational Research in the Department of Thoracic/Head and Neck Medical Oncology, successful candidates will engage in innovative translational research aimed at unraveling the immune-mediated mechanisms of tumor response and resistance to therapy in non-small cell lung cancer.

This fellowship offers a unique and exciting opportunity to contribute to cutting-edge, high-impact projects at the intersection of preclinical discovery and clinical application. Research will involve both state-of-the-art murine models and biospecimens from pioneering clinical trials testing immune checkpoint inhibitors as well as standard-of-care chemoimmunotherapy regimens in patients with surgically resected non-small cell lung cancer.

If you are passionate about translating scientific discovery into therapeutic innovation and thrive in a collaborative, mission-driven research environment, we encourage you to apply.

LEARNING OBJECTIVES
Key Research Focus
Mechanistic studies of immune checkpoint blockade in lung cancer
Analysis of tumor-immune interactions in response and resistance to therapy
Regulation of systemic and local anti-tumor immunity under therapeutic pressure
Utilization of syngeneic and genetically engineered mouse models
Integration of human clinical data with experimental immunology
Contribution to the development of novel combination strategies and biomarkers

What We Offer
A collaborative, high-energy environment at a top-ranked cancer center
Close mentorship from a physician-scientist involved in leading clinical trials
Access to cutting-edge technologies, including immunogenomics, single-cell and spatial transcriptomics, flow cytometry, and immune profiling
Opportunities for first-author publications, grant development, and career advancement
Competitive salary and comprehensive benefits

ELIGIBILITY REQUIREMENTS
Required:
Ph.D., M.D./Ph.D., or equivalent in tumor immunology, molecular biology, cancer biology, or related fields
Demonstrated experience with immune checkpoint inhibitors, T cell-based therapies, or tumor immunology
Proficiency in handling and analyzing murine cancer models, particularly syngeneic systems
Strong experimental, analytical, and communication skills
Self-motivated, collaborative, and driven to make a scientific impact

Preferred (but not required):
Familiarity with oncogenic signaling, biomarkers of response/resistance, or cancer metabolism
Experience with multi-omics approaches, such as immunogenomics or transcriptomics
Background in evaluating human tumor samples and integrating clinical data

ADDITIONAL APPLICATION INFORMATION

POSITION INFORMATION
MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000 . depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits , including medical, dental, paid time off , retirement , tuition benefits, educational opportunities, and individual and team recognition 12/31/2026 Apply Postdoctoral Fellow - Experimental Therapeutics Houston, TX College Student - Cancer Biology (The Shalapour Lab) Houston, TX Be more at MD Anderson