Sr. Scientist - LNP Formulation

Work Schedule

Environmental Conditions

Job Description

At Thermo Fisher Scientific, youll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on now and in the future.

Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission to enable our customers to make the world healthier, safer, and cleaner.

Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.

• Manufacture small and large scale LNP formulations including production, purification and analysis of LNPs using established protocols.
• Optimize formulation processes, such as mixing rate and purification conditions to improve yields and scalability of formulation.
• Troubleshoot low-yield processes and compositions to achieve formulation targets (i.e., composition design to enable specific delivery outcomes).
• Troubleshoot challenges arise during protocol execution and identify opportunities for protocol and/or process improvement.
• Meet established deadlines.
• Maintain clear and complete ELN-based experimental records.
• Follow SOPs to generate and maintain thorough and accurate documentation.
• Collect data systematically, interpret and synthesize results into cohesive conclusions.
• Generate custom lipid-based formulations and targeting molecules to optimize LNP delivery for various tissues.
• Apply and develop assays to assess delivery efficiency and payload potency.
• Openly communicates challenges and proposes solutions.
• Generate custom lipid-based formulations and targeting molecules to optimize LNP delivery for various tissues.
• Apply and develop assays to assess delivery efficiency and payload potency.

• Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar
• Sr. Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4+ years)
• OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years)
• OR PhD

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

• Extensive hands-on experience in various LNP formation mixing technology and purification methods.
• Ample hands-on experience on LNP purification techniques including but not limited to TFF and size exclusion-based purification.
• Complete knowledge and experience on various LNP analytics including but not limited to Size, PDI, RNA encapsulation, Osmolality, and Endotoxin measurement.
• Previous experience in LC-MS based LNP analytics.
• Design and contribute to scale up LNP process development experiments focused on maintaining product quality and reducing cost of goods.
• Exemplary work ethic and commitment to self-development and self-improvement
• Strong interpersonal and organizational skills

Below is listed the working environment/requirements for this role:

Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.

Able to work upright and stationary and/or standing for typical working hours.

Able to lift and move objects up to 25 pounds

Able to work in non-traditional work environments.

Able to use and learn standard office equipment and technology with

proficiency.

May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.

Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!