Postdoctoral Fellow-MSH-32076-152

The Louai Labanieh Lab is seeking motivated postdocs to develop, characterize, and test novel biotechnology platforms for: i) the precise in vivo delivery of genetic cargo and ii) regulation of immune cell function. These projects are focused on making safer and more effective cell therapies (e.g., CAR-T) and gene therapies for cancer and beyond. We are an interdisciplinary lab spanning the fields of synthetic biology, immune cell engineering, protein engineering, and immunology, with an eye towards clinical translation. Postdoctoral fellows will gain extensive experience with cutting-edge methodologies in T cell engineering, gene editing, viral vector engineering, single-cell omics, and in vivo gene delivery. This is a unique opportunity for passionate scientists to develop next-generation cell and gene therapies that overcome pressing clinical challenges with the potential to provide curative therapies for patients suffering from cancer and other debilitating diseases. We aim to provide a supportive lab environment that fosters research excellence, integrity, and positivity. The Principal Investigator will work closely with trainees to help them reach their full potential and make sure they are on track to achieve their career goals.

The candidate should have a PhD and/or MD in bioengineering, immunology, cellular/molecular biology, cancer biology, or related field, and experience in wet lab research. Prior experience in cell engineering, synthetic biology, T cell biology, or protein engineering is highly desirable but not required. We encourage applications from individuals with a strong foundation in related fields who are eager to learn and contribute to our research program.

**Qualifications**

The Labanieh Lab is affiliated with the Department of Immunology and Immunotherapy, the Icahn Genomics Institute (IGI), and the Precision Immunology Institute (PrIISM). We are part of a collaborative community of bold thinkers with world renowned expertise in basic sciences and cutting-edge clinical care. The department is supported by state-of-the-art technology cores. We are located in the Icahn Building in the Upper East Side in Manhattan, one block from Central Park. The Icahn School of Medicine at Mount Sinai (ISMM) is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, which includes seven hospital campuses, and has more than 5,000 faculty and nearly 2,000 students, residents and fellows.

In addition to submitting an application through candidates are encouraged to send the following directly to Dr. Labanieh ( ... ):

+ Cover letter (indicating earliest and preferred start dates)

+ Updated Curriculum Vitae or Biosketch

+ Brief statement of research interests (<300>

+ Contact information for three references

This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW.

Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at .

**Our mission at Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.**

**Mount Sinai Health System is committed to diversity and equal opportunity**

**Responsibilities**

Technical duties include but are not limited to:

+ Lead independent research projects, including hypothesis development, experimental design, execution, and data interpretation.

+ Design and engineer novel synthetic constructs to precisely control immune cell function.

+ Analyze, visualize, and interpret data

+ Document and maintain raw data, analyzed data, constructs, and protocols in an organized manner and share them with others when needed

+ Engage in regular meetings with the Principal Investigator for project updates, scientific discussions, and career mentorship.

+ Present research findings at scientific conferences and contribute to the publication of manuscripts and grant proposals.

+ Train and mentor junior lab members

+ Assist in maintaining lab functions

+ Perform mammalian cell culture, viral transduction, and molecular cloning

+ Apply and develop methods in protein biochemistry

+ Utilize advanced microscopy techniques, including confocal microscopy.

+ Conduct functional assays to assess immune cell activity (e.g., cytotoxicity assays, proliferation assays, ELISA).

+ Perform in vivo experiments in mouse models to evaluate the safety and efficacy of bioengineered constructs and investigate underlying biological mechanisms.

+ Analyze immune cell populations by flow cytometry, RNA-seq, and ATAC-seq

+ Collaborate effectively with members of the research team.

+ Communicate clearly and concisely, both orally and in writing, and adhere to project deadlines.

+ Maintain strict adherence to laboratory safety policies and procedures.

**About Us**

**Strength through Unity and Inclusion**

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinais unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

**About the Mount Sinai Health System:**

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Reports Best Childrens Hospitals ranks Mount Sinai Kravis Children's Hospital among the countrys best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweeks The Worlds Best Smart Hospitals ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

**Equal Opportunity Employer**

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

**Compensation Statement**

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.