Senior Scientist I, DMPK

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancer harboring mutations in the RAS signaling pathway.

The Opportunity:

The DMPK Senior Scientist I will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department.

Specifically, you will:

• Participate in the discovery of novel tri-complex inhibitors of frontier oncology targets by planning and implementing DMPK strategies to drive key project decisions for advancing small molecule programs. E.g. soft-spot analysis in optimization of molecules with improved metabolic stability or permeability.

• Maintain sufficient knowledge of principles and theories to serve as a DMPK technical lead on multi-disciplinary project teams.

• Design, manage and trouble-shoot mechanistic in vitro ADME and PK studies in a timely manner, and discuss results and potential solutions/implications at internal meetings.

• Conduct innovative research to understand the underlying principles of drug absorption, distribution, and elimination of RevMed TCI compounds by generating hypotheses from available data and literature. Incorporate new concepts and experimental techniques to develop novel in vitro ADME assays and refine IVIVE approaches.

• Collaborate with external functions to provide input and guidance on the translation of nonclinical PK/PD, PK-efficacy and PK-safety relationships to humans.

• Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.

• Build and maintain strong collaborative partnerships across external functional areas, e.g., Medicinal chemistry, Biology, Cancer Pharmacology, Clinical Pharmacology,

Required Skills, Experience, and Education:

• A highly motivated individual with a PhD in Pharmaceutic Sciences or a related scientific discipline, with 5 years of experience after graduation.

• Solid knowledge and experience in the ADME/PK concepts and basic compartmental modeling software.

• Prior experience with small molecule drug discovery programs experience working as a DMPK functional representative on cross-functional project teams.

• Complete understanding of early- through late-stage development and commercial advancement.

• Excellent verbal and written communication, problem-solving and critical thinking skills.

• Thrives in a collaborative team setting and is driven by a desire to be innovative in a highly energetic and fast-paced environment.

Preferred Skills:

• Prior experience with oncology drug development.

• Industry experience of drug development is preferred.

The base salary range for this full-time position is $144,000 to $180,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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