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We are seeking a highly motivated Scientist to join the Immunology Department. Our team is focused on identifying new targets for the treatment of autoimmune and chronic inflammatory diseases through computational analysis of human disease tissue derived datasets and through the validation of targets using in vitro and in vivo experimental approaches to make an impact on patient lives. This scientist will support the development of preclinical in vitro models for immune-mediated diseases with a focus on psoriasis and rheumatoid arthritis. Candidates will be expected to be well-versed in in vitro model development for cellular assays.
We are seeking an enthusiastic, skilled, and dedicated individual to join a team that validates targets. This position requires passion, attention to detail, prior hands-on experience and teamwork.

Sterile cell culture (cell lines and primary cells)/aseptic technique
Demonstrated ability to optimize cell culture conditions, phenotypic assays
Demonstrated ability to perform PCR/gene analysis, protein/cytokine measures via ELISA/MSD and western blotting
Candidates with knowledge of the following techniques will receive extra consideration: flow cytometry, tissue explants
Proficient in maintaining accurate laboratory records and data
Analyze data, generate PowerPoint slides and present work in internal meetings
Qualifications Position will be hired based on level of experience.
Bachelors degree in molecular biology, immunology or other biological sciences with 1-4 (BS/BA) years of experience
Masters degree is desired
Excellent communication skills
Ability to collaborate with peers and their teams

We are currently seeking a highly motivated and passionate scientist in exploratory biologics to join our team in Immunology Discovery department based in Cambridge MA. The candidate will focus on making therapeutic molecules using recombinant DNA technology, expression/purification of recombinant proteins, testing purified proteins in functional cellular assays, including basic cell biology and biochemical skills. The position offers a unique opportunity for a talented scientist to work in a dynamic, innovative, and multi-disciplinary environment to develop their career at the interface of basic research and early drug discovery. The scientist will be responsible for conceptualization, designing strategies to make therapeutic reagents, execution and analysis with the overall aim of promoting innovative drug discovery. The position requires ability to work independently, have excellent technical, written and oral communication skills and work very well in a collaborative team environment.

The applicant must have a bachelors degree or masters degree in Biological Science or related field with 2-3 years of job related experience.
Extensive hands-on experience in recombinant DNA technology, design, expression and purification of recombinant monoclonal antibodies.
Motivated to execute well-thought and well-planned in vitro experiments using the tool reagents generated.
Hands-on experience in multi-color flow cytometry with both, handling flow cytometer (Canto, MACS Quant) and independently analyzing the data using analytical software such as FlowJo is required.
Proficient in carrying out ELISA/MSD to quantitate pro-inflammatory proteins.
Basic cell biology and biochemical skills: Tissue culture, Transfection, Cell line generation, SDS-PAGE, Immunoprecipitation, Western blotting etc.
Knowledge of DNA/RNA handling and other molecular biology techniques like PCR and qPCR.
Hands on experience in carrying out size exclusion chromatography (SEC) and mass spectrometry.

We are looking for a highly motivated scientist to join our Exploratory Biologics group in Discovery Research Immunology. The position offers a unique opportunity for a talented scientist to work in a dynamic, innovative, and multi-disciplinary environment to develop their career at the interface of basic research and early drug discovery. They will support the characterization of multi specific biologics for our discovery portfolio programs. Responsibilities include planning, conducting, and analyzing in vitro assays as well as presenting data findings to explore key biological questions related to Immunological diseases. The position requires ability to work independently, have excellent technical, written and oral communication skills and work very well in a collaborative team environment. The candidate should be proficient in basic laboratory techniques including experience with primary human cells.

The applicant must have a bachelors degree or masters degree in Biological Science or related field with 2-3 years of job related experience.
Motivated to execute well-thought and well-planned in vitro experiments using multi specific biologics.
Proficient in carrying out ELISA/MSD to quantitate pro-inflammatory proteins.
Basic cell biology and biochemical skills: Tissue culture, Transfection, Cell line generation, SDS-PAGE, Immunoprecipitation, Western blotting etc.
Experience in in vitro human cell culture including various types of immune cells, and cell-based assay development is required.
Proficient in isolating immune cells from human blood and tissues.
Hands-on experience in multi-color flow cytometry with both, handling flow cytometer (Canto, MACS Quant) and independently analyzing the data using analytical software such as FlowJo is required.
Experience in biologic screening in human cells is preferred.
Knowledge of DNA/RNA handling and other molecular biology techniques like PCR and qPCR.

Job Requirement