Scientist

Responsibilities:

• The Quantitative, Translational ADME Sciences (QTAS) department is seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group.

• The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays for novel biologics entities.

• The successful candidate will be experienced in the development, optimization and implementation of novel and routine LC/MS-based bioanalytical methods to support in vivo PK, TK, and PK/PD studies as well as in vitro stability characterization of therapeutic proteins, peptides, and oligonucleotides.

• Responsible for sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation.

• Operate and maintain LC/MS instruments to generate high-quality experimental data.

• Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.

• Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.

• Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.

• Communicate data interpretation internally and externally.

Qualifications:

• Degree in chemistry, pharmacology or other related fields.

• BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry.

• Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.

• Prior industry experience in drug discovery/development is preferred.

• In-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired.

• Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is highly desired.

• Hands-on experience with automated liquid handling systems is highly desired.

• Hands-on experience with oligonucleotide analysis is highly desired.

• Experience on routine LC/MS-based bioanalysis to support in vivo PK, TK, and PK/PD studies

California Fair Chance Act:

Synectics Inc. will consider qualified applicants with a criminal history pursuant to the California Fair Chance Act. You do not need to disclose your criminal history or participate in a background check until a conditional job offer is made to you. After making a conditional offer and running a background check, if Synectics Inc. is concerned about conviction that is directly related to the job, you will be given the chance to explain the circumstances surrounding the conviction, provide mitigating evidence, or challenge the accuracy of the background report. Find out more about the Fair Chance Act by visiting calcivilrights.ca.gov/fair-chance-act/.

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance : Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.