Senior Scientist, Downstream

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

Position Summary

Join Bristol Myers Squibb's dynamic Manufacturing Sciences & Technology (MS&T) laboratory team, where you will play a critical role in supporting commercial manufacturing and process technology transfer for biopharmaceuticals. As a Senior Scientist specializing in downstream processes, you will contribute your expertise in purification and primary recovery within a diverse, highly technical, and collaborative team of scientists and engineers.

The successful candidate will act as a subject matter expert and key contributor to the MS&T organization. MS&T scientists and engineers work across functional teams to achieve high-impact business objectives and ensure robust, compliant, and efficient manufacturing operations. This position offers significant exposure to partner functions including Manufacturing, Manufacturing Technology, Bioprocess Development, Quality Assurance, Analytical, and Global Regulatory Sciences.

Key Responsibilities:

• Lead downstream process support for commercial manufacturing and technology transfer activities.

• Provide technical input for process investigations, including root cause analysis and implementation of corrective and preventive actions (CAPAs).

• Drive continuous improvement initiatives to enhance process robustness, efficiency, and compliance.

• Support downstream activities for technology transfer, process validation, and preparation of Chemistry, Manufacturing, and Controls (CMC) documentation.

• Contribute to regulatory filings and interface with regulatory agencies, including support for inspections and responses to inquiries.

• Design and execute technical studies to support manufacturing investigations or technology transfer of new processes. This includes leveraging laboratory and scale-down models for:

  • Protein chromatography

  • Viral inactivation

  • Viral filtration

  • Ultrafiltration/diafiltration

  • Membrane filtration

  • Depth filtration

  • Centrifugation

• Document and verify experimental data, interpret results in alignment with lab protocols and manufacturing processes, and generate comprehensive technical reports.

• Collaborate effectively with partners across MS&T, Manufacturing, Process Development, Quality, and Regulatory to align on technical strategies and execution.

• Evaluate emerging downstream process technologies and recommend improvements as appropriate.

• Demonstrate strong written and verbal communication skills to clearly convey technical data and conclusions.

Qualifications & Experience:

• Degree in Chemical/Biochemical Engineering, Biochemistry, or a related discipline:

  • BS with at least 7 years of relevant industry experience

  • MS with at least 5 years

  • Ph.D. with 24 years

• Strong scientific understanding of protein purification and stability.

• Proficiency with downstream processing equipment and techniques, including:

  • AKTA chromatography systems

  • Ultrafiltration/diafiltration systems

• Experience with viral clearance processes is preferred.

• Demonstrated scientific curiosity, critical thinking, and collaborative problem-solving.

• Effective communicator with strong technical writing skills.

• Ability to operate in a regulated environment with understanding of GMP manufacturing impact, though laboratory work is performed in a non-GMP setting.

The starting compensation for this job is a range from $120,740 to $146,300, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

#LI-Onsite

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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