Senior Research Associate, Genome Engineering

Who is BlueRock? BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases. The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel cell+gene platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.
What Are We Doing? Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit. We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options. We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients lives.
Description of Position: The New York, USA site is seeking to fill a Senior Research Associate position for the PSC Biology pipeline. The role will fit a motivated individual with a background in stem cell biology and genome engineering who will be a technical contributor in a dynamic and progressive team. Within an exciting collaborative environment, the individual will contribute to projects that involve human pluripotent stem cell (hPSC) derivation, banking, engineering and differentiation, to establish and characterize cell lines for BlueRocks research pipeline that are altered in their genome to provide novel morphology or function. Responsibilities

• Execute in vitro experiments to characterize and cultivate hPSCs and their derivatives.
• Collaborate cross-functionally with stakeholders in other platform and program teams to characterize engineered or reprogrammed cell lines.
• Perform DNA/RNA-based, cell-based, flow cytometric, immunofluorescence and other protein-based analytical assays as required.
• Analyze and document experimental data in electronic laboratory notebooks in a timely and accurate manner in accordance with the company quality management system.
• Be responsible for data generation, collection, interpretation and communication of results.
• Prepare and follow standard operating procedures, batch records and other process documentation.
• Attend and present scientific data to colleagues at internal meetings.

Minimum Requirements

• B.S. or M.Sc . in cell biology, molecular biology, genetics or related discipline, with a minimum of 5 years (B.S.) or 3 years ( M.Sc .) laboratory research or industry experience.
• Strong experience with human pluripotent stem cell or mammalian cell culture.
• Experience with cell characterization technologies including PCR, DNA sequencing, qPCR, flow cytometry and immunofluorescence.
• Experience with gene editing and iPSC reprogramming technologies is advantageous.
• Experience with cell transfection techniques is preferred.
• Knowledge of lineage-specific differentiation of human pluripotent stem cells is advantageous.
• Experience with DNA design software is preferred.
• Excellent analytical, problem solving and organizational skills.
• Strong written and verbal communications skills.