Sr. Research Scientist, Toxicology

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)

The Senior Research Scientist, Toxicology, provides toxicology support to assigned program(s), with functions in necropsy, histology, and clinical pathology.

Essential Functions of the Job (Key responsibilities)

• Performs necropsy of mice and rats, oversees necropsy setup, cutting, and trimming. Assist in managing the necropsy facility. Assists in training team members to perform mice and rat necropsies. Has a working knowledge of the software system (Pathology Data Systems, PDS) used for data collection of macroscopic findings and organ weights. Proficient in using the software to set up studies for data collection.
• Perform Clinical Pathology setup and instrument maintenance according to study requirements. Collect and analyze hematology and clinical chemistry samples using current in-house equipment, ensuring accessibility for all team members. Demonstrate knowledge of analyte ranges, data interpretation, control data, and calibration data. Utilize software (PDS) for the collection and quality control of clinical pathology data, ensuring inclusivity and accessibility in data handling.
• Preparation of histology slides from tissues from both large animal studies (e.g., dog, monkey) in collaboration with CRO's and small animals (e.g., rat, mouse) in-house studies, including trimming, processing, embedding, sectioning, and H&E staining. Assist with quality assessment of the pathology slides. Working knowledge of maintenance of the instrumentation to perform these functions.
• Preparation of immunohistochemically stained tissues sections and organic stained tissue sections on a per study basis.
• Archive gross tissues, tissue cassettes, and slides. This includes the receipt, reading and return of slides from GLP and non-GLP peer review studies.
• Collaborate and support other groups in the method development of animal models. Working knowledge of cell culture preparation, alternative media preparation, and whole blood assays is preferred, but not required.
• Assist in quality assurance of data and reports generated by the pathology group.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Degree in Biology/Medical Technology or a related field, or equivalent education and experience.
• Significant experience in a relevant scientific discipline, with a focus on skills and knowledge over years of experience.
• ASCP HT or other medical technology certification preferred but not required.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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