Sr. Scientist Structural Biology

About This Role

We're looking for a Senior Scientist with extensive structural biology experience and a passion for structure-based drug design. In this role, you'll be instrumental in determining novel cryo-EM and crystal structures, driving insights into mechanisms of action, and contributing to protein engineering using cutting-edge technologies. You'll play a key role in-house cryo-EM lab, including our Glacios cryo-EM microscope, and leverage structural data and generative models to advance drug discovery projects. This is an exciting opportunity to join a dedicated, innovative team focused on addressing unmet medical needs.

What You'll Do

• Determine novel cryo-EM and X-ray crystal structures of protein-small molecule and antigen-antibody complexes
• Support day-to-day operations of the cryo-EM lab, including routine maintenance and instrument monitoring
• Drive insights into mechanism of action and structure-function relationships for engineering
• Utilize a multi-disciplinary approach including state-of-the-art biophysical and structural techniques
• Evaluate external opportunities towards new experimental and de novo design computational approaches
• Contribute to a fast-paced, innovative team pursuing unmet medical needs in neuroscience and rare diseases

Who You Are

You are passionate about structural biology and adept at leveraging structural insights to impact drug discovery projects. You thrive on learning new technological skills and excel in collaborative environments.

Required Skills

• Ph.D. in Biochemistry, or a related discipline, with 2+ years post-Ph.D. experience
• Expertise in single particle Cryo-EM, from sample preparation to 3D model building
• Expertise in X-ray crystallography, from crystallization to 3D model building
• Proven track record solving challenging membrane protein structures
• Working experience with Linux and High Performance Computing clusters
• Skilled in multi-body and focused refinement strategies for flexible complexes
• Experience in leveraging structure-based generative models for protein design
• Ability to work independently and collaboratively within a team
• Strong communication and interpersonal skills

Job Level: Management

Additional Information

The base compensation range for this role is: $121,000.00-$162,000.00

Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being; including, but not limited to:

• Medical, Dental, Vision, & Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short- and Long-Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.