Senior Scientist, DMPK

Job Description

The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) function of our Research & Development Division at South San Francisco is seeking a dynamic and collaborative scientist for the Drug Metabolism and Pharmacokinetics (DMPK) group. The Senior Scientist will be a member of the function providing expertise as a key component of the multi-disciplinary drug discovery effort in our Research & Development Division at South San Francisco, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology. Therapeutic areas may include immunology and oncology, cardiovascular and metabolic disease, and ophthalmology.

The Senior Scientist will be a member of the DMPK function providing expertise as a key component of the multi-disciplinary drug discovery effort in our Research & Development Division at South San Francisco, with a focus on supporting preclinical development of next generation biologics, antibody drug conjugates (ADC), small molecule and peptide using liquid chromatography-mass spectrometry (LC-MS) technologies. The Senior Scientist will contribute to the LC-MS based quantitation analysis of PK samples and also biotransformation investigation of next gen biologics and Antibody Drug Conjugate (ADC) using liquid chromatography-mass spectrometry (LC-MS). Ideal candidate is expected to independently plan and conduct in vitro/ex vivo studies, independently interpret data, clearly present data to teams, and integrate data to inform pipeline decisions. The candidate will contribute to scientific initiative for further understanding in DMPK science.

The successful candidate should be an experienced scientist with knowledge and hands on experience in HRMS operation/maintenance and quantitative/qualitative mass spec analysis of protein/peptide. Hands on experience with bioanalysis in DMPK space, global/targeted proteomics and cell-based assay is a plus. and associated informatic tools. The candidate must be able to work collaboratively in a fast-paced environment and have excellent scientific, interpersonal and communication skills.

P osition qualifications:

Education:

• Bachelor's (with 7 years), Master's (with 4 years) or Ph.D. in analytical chemistry, biochemistry, chemical biology, cell biology, pharmaceutical sciences, biology, chemistry, pharmacology, biochemical engineering or a related discipline and relevant experience

Required Experience and Skills:

• Experience with high resolution mass spectrometers technologies (e.g. TOF, Orbitraps)

• Experience with maintaining and troubleshooting HPLC and mass spectrometers

• Demonstrated extensive experience in protein/peptide identification, quantitation and characterization using mass spectrometers, e.g. bioanalysis and biotransformation analysis of protein biotherapeutics, global or targeted bottom-up proteomics, peptidomics, top-down proteomics, etc.

• Demonstrated proficiency in designing and performing hypothesis-driven experiments

• Expertise with software such as Proteome Discoverer, Skyline, Genedata and other mass spectrometry software packages.

• Highly motivated, self-driven and results-oriented individual with excellent communication and presentation skills.

• An excellent team player that can closely collaborate with internal and external collaborators

Preferred Experience and Skills:

• Previous experience in biologics/ADC PK sample LC-MS analysis is preferred but not required

• Previous experience with Watson LIMS, Sciex Triple Quads and MultiQuant is a plus but not required.

• Previous experience in drug discovery and development is a plus but not required.

• Previous experience in cell culture is a plus but not required.

• General knowledge of PK, ADME and/or drug discovery concepts.

• High learning agility and a willingness to contribute to all levels within the DMPK group.

• Demonstrated creativity and innovation via a publication/presentation record.

• Comfortable with risk taking and undertaking hypothesis-driven experimentation

#EligibleforERP

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .

You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Required Skills:

Preferred Skills:

Job Posting End Date:

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.