Scientist, Discovery & Translational Research

Contribute to Alnylam's growing pipeline by identifying new siRNA drug-targets that are based on human genetics, literature, academic collaborations, genomic approaches, etc. across the cardiometabolic space. Design and execute proof of concept experiments in animal and in vitro disease models. Design studies, coordinate activities, and lead from the bench. Work closely with Alnylam's human genetics, multi-omics, platform and clinical teams to identify promising novel drug targets. Develop assays to monitor target engagement/pharmacodynamic responses. Oversee lead discovery activities for the selection of drug candidates for further development. Work with multifunctional teams to shepherd a drug candidate through the lead selection and development process to the clinic. Manage relationships with contract research organizations (CROs) and/or academic collaborators, including development of research plans and data analysis. Mentor junior scientists. Collaborate and communicate results with key stakeholders throughout organization. PhD in biology or biomedical sciences-related field. Post doc or 1-2 years of experience preferred. Strong publication record. Individuals with expertise in cardiometabolic diseases (e.g., diabetes, obesity, dyslipidemia) are strongly encouraged to apply. Existing focus on disease biology and prior experience with in vivo mammalian disease models is also preferred. Solid organizational skills and ability to multitask are a must. The successful candidate will have strong interpersonal and communication skills, track record of working on teams, interest in learning new biology and passion for lab work.