Senior Principal Scientist, Biological Network Analytics

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at

**Job Function:**

Discovery & Pre-Clinical/Clinical Development

**Job Sub** **Function:**

Biological Research

**Job Category:**

Scientific/Technology

**All Job Posting Locations:**

Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America

**Job Description:**

**About Innovative Medicine:**

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at

**We are searching for the best talent for a Senior Principal Scientist, Biological Network Analytics** **to be located in Spring House, PA or Cambridge, MA.**

**Purpose:**

We are seeking an innovative, collaborative computational biologist to be part of the Biological Network Analytics team within the broader Multiomics Discovery team, which is responsible for addressing omics and imaging related questions throughout the drug discovery process (from novel target identification and reverse translation to compound optimization) using various high-throughput and high-dimensional technologies. The successful candidate has a strong background in quantitative omics analysis within a drug discovery context. They will need to partner effectively with wet-lab teams to design appropriate experiments, analyze data, interpret results and communicate findings. As the domain is inherently interdisciplinary, they will need to interact with project leads, other data scientists, IT, statisticians, and thus excellent cross-functional communication is an integral part of the desired skill set.

This role will directly support the broader Multiomics Discovery efforts through integration and analysis of multiple high dimensional biology datasets within the Biological Network Analytics group and contribute to the understanding of complex biology through advanced data analysis methods.

**You will be responsible for** **:**

+ Design, develop, and validate sophisticated models and algorithms to characterize biological processes and networks at the system level

+ Architect strategies for integrating large-scale datasets including NGS, proteomics, high-content imaging, and other modalities across multiomics platforms

+ Apply network analysis and systems biology principles to identify key pathways and interactions critical to disease pathogenesis

+ Collaborate with wet lab teams for experimental design, and with data scientists, IT, statisticians, and external partners to translate insights into actionable hypotheses

+ Support therapeutic project teams with data-driven recommendations, fostering innovation in target discovery, biomarker development, and compound optimization

+ Communicate findings through presentations, executive summaries and publications

+ Lead internal and external innovation partnerships

**Qualifications / Requirements:**

**Education:**

+ A minimum of a Bachelor's degree is required

+ Advanced degree (PhD) in Cell Biology, Molecular Biology, Computational Biology, Bioinformatics or related discipline is highly preferred

**Required:**

+ Minimum 8-10 years of experience in biotech or pharmaceutical industry

+ Proven expertise in systems biology, network modeling, and multiomics data integration

+ Strong programming proficiency in Python, R, and relevant analysis tools

+ Knowledge of machine learning algorithms, statistical modeling, and unsupervised analysis techniques

+ Demonstrated leadership in developing innovative algorithms, models, and analytical frameworks

+ Exceptional communication skills, with a track record of publishing impactful research and effectively guiding cross-disciplinary teams

+ Experience managing complex projects and multi-stakeholder collaborations

+ Experience as a problem solver and team collaborator; able to facilitate understanding between biologists and data scientists

+ Up to 10% travel Domestic & International

**Preferred:**

+ Understanding of disease biology, preferably in immunology, oncology or neuroscience

+ Expertise in single cell and spatial omics technologies

+ Knowledge of cellular assay development and applications in drug discovery

+ Track record of integrating external collaborations into research programs

+ Strong background in statistical analysis and data visualization

+ Experience with cloud computing, HPC infrastructure, and workflow management tools (e.g., Nextflow)

The anticipated base pay range for this position in the US is $137,000 to $235,750

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/ performance year. Bonuses are awarded at the Companys discretion on an individual basis.

Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.

Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

Employees are eligible for the following time off benefits:

+ Vacation - up to 120 hours per calendar year

+ Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year

+ Holiday pay, including Floating Holidays - up to 13 days per calendar year

+ Work, Personal and Family Time - up to 40 hours per calendar year

For additional general information on company benefits, please go to:

This job posting is anticipated to close on August 12, 2025. The Company may however extend this time-period, in which case the posting will remain available on to accept additional applications.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.

\#LI-Hybrid

**The anticipated base pay range for this position is :**

$137,000-235,000

Additional Description for Pay Transparency:

Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Companys long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation 120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year Holiday pay, including Floating Holidays 13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave 480 hours within one year of the birth/adoption/foster care of a child Condolence Leave 30 days for an immediate family member: 5 days for an extended family member Caregiver Leave 10 days Volunteer Leave 4 days Military Spouse Time-Off 80 hours Additional information can be found through the link below.