Senior Scientist, Peptide Chemistry

Position Summary

We are seeking a highly skilled and motivated Senior Scientist specializing in Peptide Chemistry to join our dynamic research and development team. The ideal candidate will play a key role in the design, synthesis, purification, and characterization of novel peptide-based therapeutics, contributing directly to the advancement of our drug discovery pipeline.

Reporting to our Director of Chemistry, this position offers an exciting opportunity to lead and collaborate within a multidisciplinary team, driving innovation and scientific excellence in the field of peptide chemistry. The successful candidate will work closely across discovery chemistry and discovery biology, including partnerships with the CMC formulation group and the MBX Discovery Team, to ensure seamless integration of peptide candidates into broader therapeutic development efforts.

Key Responsibilities

• Lead the design and execution of complex synthetic routes for the development of novel peptide-based compounds, ensuring high-quality and efficient synthesis processes.
• Utilize advanced analytical techniques, such as HPLC, MS, NMR, and other spectroscopic methods, to characterize and validate the biophysical stability of synthesized peptides.
• Conduct thorough literature reviews and stay abreast of the latest developments in peptide chemistry and related fields, integrating new knowledge and methodologies into research projects.
• Collaborate with cross-functional teams to develop and optimize peptide-based drug candidates, contributing to the evaluation of structure-activity relationships and pharmacokinetic properties.
• Actively participate in the planning and implementation of research strategies, including the design of experimental protocols, data analysis, and interpretation to support the achievement of project milestones.
• Mentor and provide guidance to other scientists, fostering a collaborative and intellectually stimulating environment for scientific growth and development.
• Contribute to the drafting of research reports, publications, and patent applications, effectively communicating scientific findings and discoveries to internal stakeholders and the broader scientific community.
• Maintain a strong commitment to laboratory safety, adhering to established protocols and practices, and ensuring compliance with regulatory guidelines and industry standards.
• Uphold Good Laboratory Practices (GLP) and prioritize safety at all times, actively contributing to a proactive and safety-focused culture.
• Other responsibilities as assigned.

Education

• BS, MS or Ph.D. in Organic Chemistry, Chemical Biology, or a related discipline with a focus on peptide chemistry

Experience

• A minimum of 7+ years of relevant industry experience in peptide synthesis, purification, and characterization, preferably within a biotechnology or pharmaceutical research environment.
• Strong problem-solving skills with detail understanding of "side reactions" related to peptide synthesis
• Expert level peptide purification, isolation, and analytical skills
• Proven expertise in the design and execution of complex synthetic strategies, as well as in-depth knowledge of modern peptide chemistry techniques and methodologies
• Proven experience in building complex peptides with multiple modifications
• Strong proficiency in utilizing analytical instruments, such as HPLC, MS, and other spectroscopic tools, for the characterization and analysis of peptide compounds
• Experience with physical characterization of peptides such as size exclusion chromatography, fibrillation assay, peptide purity assessment, etc...
• Strong technical problem-solving skills both independently and as part of a team
• Demonstrated ability to work effectively in a collaborative team environment, with excellent communication skills and a track record of successful interdisciplinary collaboration
• A strong publication record in reputable scientific journals and/or demonstrated ability to contribute to intellectual property development through patent applications or related activities.

Company Overview:

MBX Biosciences, Inc. (NASDAQ: MBX) is a clinical-stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders. The Company was founded by global leaders with a transformative approach to peptide drug design and development. Leveraging this expertise, the Company designed its proprietary Precision Endocrine Peptide (PEP) platform to overcome the key limitations of unmodified and modified peptide therapies and to improve clinical outcomes and simplify disease management for patients. PEPs are selectively engineered to have optimized pharmaceutical properties, including extended time-action profiles and consistent drug concentrations with low peak-to-trough concentration ratios, consistent exposure to target tissues, and less frequent dosing. The Company is advancing a pipeline of novel candidates for endocrine and metabolic disorders with clinically validated targets, established endpoints for regulatory approval, significant unmet medical needs and large potential market opportunities. The Company's pipeline includes its lead product candidate MBX 2109, in Phase 2 development for the treatment of chronic hypoparathyroidism (HP); MBX 1416, in Phase 1 development for the treatment of post-bariatric hypoglycemia (PBH); and an obesity portfolio that includes MBX 4291, as well as multiple discovery and pre-clinical candidates in development for the treatment of obesity. The Company is based in Carmel, Indiana. To learn more, please visit the Company website at www.mbxbio.com and follow us on LinkedIn.

EEO Statement:

MBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.