Principal Research Scientist - Enzymology - Wilmington, DE

Description

Principal Research Scientist - Enzymology - Wilmington, DE

Syneos Health is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities.

Our Clinical Development model brings the customer and the patient to the center of everything that we do. We are continuously looking for ways to simplify and streamline our work to not only make Syneos Health easier to work with, but to make us easier to work for.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you'll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies, because we are passionate to change lives.

Discover what our 29,000 employees, across 110 countries already know:

WORK HERE MATTERS EVERYWHERE

Why Syneos Health

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to our Total Self culture - where you can authentically be yourself. Our Total Self culture is what unites us globally, and we are dedicated to taking care of our people.
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because when we bring together diversity of thoughts, backgrounds, cultures, and perspectives - we're able to create a place where everyone feels like they belong.

Job Responsibilities

• Design, develop, and execute a variety of biochemical (FI, HTRF, FP etc.) and biophysical assays (SPR, BLI, ITC, DSF etc.) to support hit identification, validation, and mechanistic studies of various modalities, including inhibitors, activators and degraders.
• Troubleshoot assay performance issues by analyzing assay variability, signal-to-noise ratios, reagent stability, and optimize protocols for robustness, scalability, and reproducibility.
• Perform high-throughput screening (HTS) and related assays to evaluate compound libraries, assessing affinity, specificity, and binding kinetics (e.g., IC, Kd, kon, koff).
• Analyze and interpret experimental data using tools such as GraphPad Prism, Genedata Screener, and other curve-fitting or statistical software, present findings in clear and concise reports, slide decks, and collaborative discussions.
• Support protein expression and purification workflows using techniques such as affinity chromatography, ion-exchange chromatography, and size-exclusion chromatography to generate high-quality proteins for downstream biochemical and biophysical assays.
• Operate and maintain a wide range of lab instrumentation including multimode plate readers, automated liquid handlers etc.
• Maintain accurate and timely electronic lab notebooks (ELN), contribute to technical documentation as needed.

Qualifications

• Master's or Ph.D. in Chemistry, Biochemistry, Biophysics, Chemical Biology, or a related field, with extensive lab experience in biochemistry or enzymology setting (0-5 years of experience)
• Fundamental understanding of enzymology, biochemical assays and biophysics (e.g., enzyme catalysis and small molecule modes of action, kcat, Km, IC50, Kd, kon, koff).
• Experience in basic biochemistry lab work, such as preparing buffers, reagents generations, assay development and performance, operating liquid handling platforms, plate readers etc.
• Hands-on experience with protein purification and characterization, demonstrating familiarity with theoretical aspects of relevant methods.

At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.

Salary Range:

The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate's qualifications, skills, competencies, and proficiency for the role.

Get to know Syneos Health

Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.

No matter what your role is, you'll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.

Additional Information

Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.