Scientist, RNA Conjugation & Synthesis

Conjugate novel ligands, including small molecules, peptides, and proteins, to oligonucleotides for delivery. Help to oversee and improve purification of oligonucleotides using various chromatography techniques. Collaborate with biology and chemistry colleagues to identify priority ligand-receptor pairs and develop targeting strategies. Design and execute the automated synthesis, purification, and analysis of siRNAs with various chemistries and scales using state-of-the-art instrumentation platforms. Improve and/or develop new processes to expand upon current capabilities. Troubleshoot and perform routine maintenance on critical instrumentation such as automated synthesis platforms, HPLC, and liquid handling robots. Work closely with members across various sub teams within RNAi discovery. Analyze, organize, and present data at internal meetings. PhD in Chemistry, Biochemistry, or related discipline with 0-3 years post-degree experience in an industrial or academic setting. Experience in conjugation/bioconjugation chemistry.Solid-phase synthesis techniques with oligonucleotides or peptides is desired. Expertise in chromatography purification techniques and troubleshooting. Strong laboratory skills and experience with analytical instrumentation such as HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data. The ability to apply his/her knowledge to a new area of study as well as to thrive in a highly interdisciplinary team environment with excellent oral and written communication skills.