Principal Scientist, Immunology Discovery

Job Description

Our Company's Discovery Immunology groups are developing a world class pipeline to treat immune mediated diseases across Gastroenterology, Rheumatology and Dermatology. We are seeking an exceptional scientific leader with deep expertise in Immunology Discovery to join our vibrant Research & Discovery team in San Diego in our journey to discover and develop the next generation of best-in-class medicines that will raise the therapeutic ceiling in the treatment of immune-driven diseases.

This role will report to the Associate Vice President, Immunology Discovery. You will serve as Discovery Immunology Project lead on early-stage immunology programs, driving projects from scientific rationale for target ID through translational research, target validation, differentiation, derisking, modality selection, and overall strategy through the Discovery stages. Collaborating with Discovery Biologics, Chemistry, Quantitative Biology, and other functions at Our Company, you will be defining and executing the discovery strategy for multiple programs. The role also will be responsible for early biomarker discovery for portfolio pipeline programs in immunology and its successful and timely transition to the Translational Medicine Team for incorporation into the clinic.

Key Responsibilities:

• Work with the Associate Vice President Immunology Discovery SD Research & Development Division and other project leads on site as well as other Research & Development Division Immunology Discovery sites to define and execute drug discovery immunology programs in the portfolio as part of the Immunology TA strategy

• Work closely with a cross-functional group of experts across Our Company to design and execute the Research Operating Plan to advance projects through Discovery

• Lead the discovery and creation of cellular, molecular and functional assays required for design and execution of the Research Operating Plan to advance projects through Discovery and toward early development

• Partner closely with cross functional colleagues including Computational Scientists (DAGS), modelers, PKPD, to advance projects forward through stages of Discovery.

• Contribute to discovery and creation of translational data actionable science packages to identify, validate and execute novel targets implicated in the pathogenesis of TA disease areas including Derm, Rheum and GI

• Lead the discovery and creation of cellular, molecular and functional assays that can serve as biomarkers for prosecution of programs as they advance through the Discovery stages toward Early Development

• Collaborate with Translational Medicine Biomarker colleagues for programs moving toward Early Development to ensure transition of early discovery biomarkers and biomarkers plans for execution during development stages

• Champion the use of new technologies and modalities to drive discovery and prosecution of novel targets in immunological disease through various modalities and approaches including small molecules, peptides, biologics, T cell engagers and others.

• Contribute to the overall company's Immunology TA strategy

• Maintaining awareness of scientific developments within area of expertise, in terms of new scientific findings, research methodologies, novel platforms and modalities

• Attend appropriate scientific meetings to maintain cutting edge knowledge and competency

To accomplish these goals, the Senior Principal Scientist may:

• Author detailed development documents, presentations, budgets, and position papers for internal and external audiences

• Collaborate with external experts/researchers around the world with a specific interest and expertise related to Immunopathogenesis of immunological diseases and biomarkers in immunology

• Travel on company business about 20% of the time to manage cross-functional work for ongoing research projects and to attend scientific meetings or Immunology TA meetings

Qualifications:

Education:

• Master's (with 10+ years) or Ph.D. (with 7+ years) in Biological Sciences or related field and relevant immunology experience

Required Experience and Skills:

• Prior experience in discovery research in the field of immunology

• Strong knowledge of the molecular and cellular pathways in the pathogenesis of immune mediated disease and the application of cellular, molecular technologies and models to drive programs forward

• Experience in biomarkers and translational research

• Leadership / people management experience

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .

You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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