Principal Scientist, Medicinal and Structural Chemistry

At Gilead, were creating a healthier world for all people. For more than 35 years, weve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gileads team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and were looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Principal Scientist, Medicinal and Structural Chemistry

NMR Analytical Chemist

This role represents an opportunity to maintain and further develop Gileads NMR facility and its impact on Gileads Small Molecule Drug Discovery organization toward achieving our goal of discovering transformational medicines. The ideal candidate will bridge the disciplines of NMR spectroscopy and medicinal chemistry through a deep knowledge of both fields as applied to small molecule drug discovery.

Responsibilities

• NMR Strategy : Further develop the strategy for NMR spectroscopy and enhance capabilities to include seamless data analysis workflows and quantitative NMR analysis.

• Instrument Maintenance : Responsible for maintaining existing NMR facility to ensure optimal performance and to support Gileads Medicinal Chemistry research organization.

• Structural Elucidation : Obtain and interpret multidimensional NMR data of small molecules and provide detailed reports and insights on chemical structures and properties.

• Method Development : Develop and optimize traditional and novel NMR methods for various applications.

• Documentation : Maintain accurate and detailed records of all experiments, analyses, and results in accordance with industry standards and regulatory requirements.

• Training and Support : Provide training and technical support to junior staff and other team members on NMR techniques and instrument operation.

• Collaboration : Collaborate and communicate effectively with medicinal chemistry colleagues and cross-functional teams.

Required Qualifications

• Ph.D. (with 5+ years) in organic chemistry, or equivalent discipline with an emphasis in NMR techniques and methods.

OR

• Master's (+8 years) in organic chemistry, or equivalent discipline with an emphasis in NMR techniques and methods.

OR

• Bachelor's (+10 years) in organic chemistry, or equivalent discipline with an emphasis in NMR techniques and methods.

Preferred Qualifications

• Strong knowledge and experience in NMR spectroscopy with proven applications in the pharmaceutical industry. Demonstrated ability to obtain and analyze NMR data to perform structure elucidation in a medicinal chemistry environment.

• Strong data processing and analysis skills including coding language for data analysis and database management.

• Comprehensive knowledge of Bruker NMR instrumentation and software, methodology and Mnova NMR software.

• Excellent troubleshooting skills and ability to develop and optimize analytical methods.

• Effective written and verbal communication skills, with the ability to present findings clearly and concisely.

• High level of accuracy and attention to detail in all aspects of work.

• Strong synthetic skills and a solid knowledge of modern organic synthesis techniques

• Experience with latest NMR techniques to elucidate interactions between small molecules and their drug targets.

• Experience with NMR based fragment screening methods.

• Experience with the use of liquid handlers for NMR sample preparation. Experience conducting multi-step organic synthesis.

• Recent experience conducting parallel or automated synthesis.

• Knowledge of DMPK and ADME principles.

People Leader Accountabilities:

• Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.

• Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and realize their purpose.

• Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.

The salary range for this position is: $195,670.00 - $253,220.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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