Senior Scientist, Cell Therapy Analytical Development

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

Position Summary

We are seeking a highly motivated and experienced Senior Scientist with expertise in developing cell-based lot-release potency assays for gene editing materials used in cell therapy, including mRNAs and viral vectors. In this hands-on role, the successful candidate will lead the conceptualization, optimization, qualification, and transfer of potency assay methods to quality control (QC) labs. The ideal candidate will also have strong scientific and technical experience in gene editing applications, such as CRISPR, as well as analytical method development experience within a CMC environment.

Key Responsibilities

• Design, develop, and optimize QC-compatible analytical methods and potency assays (eg. flow cytometry, ELISA, cell-based reporter gene assays, qPCR/dPCR, capillary electrophoresis) to support release and stability testing of gene editing materials such as mRNAs and viral vectors.

• Identify and manage critical reagents needed to develop, execute and transfer analytical methods.
• Collaborate with QC to ensure smooth analysts training and transfer of assays for lot release and stability testing.
• Design, engineer and maintain immortalized monoclonal cell lines, including reporter gene constructs, to support the development of MOA reflective potency assays.
• Author and/or review technical documents for method development, transfer, qualification protocols and reports.
• Implement statistical tools and design of experiments (DOE) to ensure robustness and reliability of assays.
• Act as subject matter expert (SME) in analytical subteam meetings and cross-functinoal meetings (eg. QC, AS&T, CMC, Regulatory etc.).
• Evaluate new and innovative technologies for implementation into AD and QC.
• Maintain compliance with internal quality systems and relevant regulatory guidelines.

Qualifications & Experience

• MS with 6+ years, or PhD with 3+ years in analytical development, ideally in the gene therapy space.
• Proficiency in a broad range of analytical techniques used in cell and gene therapies, such as qPCR/dPCR, Flow Cytometry, ELISA, protein electrophoresis, plate-based reporter gene assays.
• Good understanding of ICH guidelines for assay qualification/validation.
• Ability to align method development with the program goals and requirements in a phase-appropriate manner.
• Extensive experience in gene editing application especially newer generations of CRIPSR editors is preferred.
• Experience collaborating across CMC functions (PD, QC, AS&T etc.) is preferred.
• Basic understanding of method lifecycle management from development to validation and beyond is preferred.

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employees work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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