Senior Scientist, Functional Genomics

Description

About Immunai

Immunai is an engineering-first platform company aiming to improve therapeutic decision-making throughout the drug discovery and development process. We are mapping the immune system at unprecedented scale and granularity and applying machine learning to this massive clinico-immune database, in order to generate novel insights into disease pathology for our partners - pharma companies and research institutes. We provide a comprehensive, end-to-end solution - from data generation and curation to therapeutics development, that continuously supports and validates the capabilities of our platform.

As drug development is becoming increasingly inefficient, our ultimate goal is to help bring breakthrough medicines to patients as quickly and successfully as possible.

Immunai is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

About the Role

As a Senior Scientist in our Discovery & Preclinical group, you will drive execution of immunology-focused projects using cutting-edge genomic technologies. You will plan and execute complex experiments, mentor junior scientists, and collaborate across teams to advance projects from target discovery to preclinical development. Your work will directly inform critical go/no-go decisions.

Location: New York City, NY (on-site)

What will you do?

• Support current Functional Genomics capabilities in order to test in-silico predictions, support target discovery, validate causal mechanisms, and evaluate preclinical stage assets
• Introduce novel Functional Genomics capabilities and other molecular biology tools and assay in order to expand internal expertise and mature a therapeutic platform
• Design and execute complex experiments to translate genomic data into actionable therapeutic hypotheses utilizing in vitro/ex vivo immune cell-based assays
• Work closely with other senior scientists, immunologists and the computational team to generate testable hypotheses and prioritize assets based on observational data and cohort studies
• Collaborate closely with the other members of the Discovery and Preclinical Applications team to identify or test hypotheses around genetic targets
• Mentor junior level scientists
• Maintain extensive knowledge of the current literature and best practices in the field
• Effectively translate insights into go/no-go recommendations to drive decisions
• Deliver impactful presentations to other colleagues including senior leadership

Requirements

Required Qualifications

• Educational Background: Ph.D. in molecular biology, genomics, immunology, or a related field.
• Industry Experience: 5+ years of relevant experience, preferably in industry setting
• Proven Expertise in Functional Genomics tools: CRISPR KO/KI and overexpression (OE) techniques and related, at low-, mid- and high-throughput scale, other gene perturbation tools, such as siRNA, mRNA is preferred
• Scientific project management: Excellent organization, time and project management skills
• Technical and Analytical Proficiency: Strong analytical skills, problem solving ability, and innovation aptitude required
• Innovative Problem-Solving and System-Level Thinking
• Strong Communication Skills: Excellent written and verbal communication, with the ability to present complex technical ideas to diverse audiences; excellent interpersonal skills and ability to effectively work as part of a team are essential

Nice-to-Have Qualifications

• Experience with immunology assay: in vitro/ex vivo immune cell-based assays, isolation and culture of primary cells from blood and tissue samples
• Experience in RNA therapeutics field: hands-on experience with the design, synthesis, and in vitro/in vivo evaluation of RNA therapeutic candidates (e.g., mRNA, siRNA, ASOs)

Desired personality:

• You want to make an impact
• You prioritize "We" over "I"
• You enjoy getting things done and striving for excellence
• You collaborate effectively with people of diverse backgrounds and cultures
• You have a growth mindset
• You are candid, authentic, and transparent

Compensation: This position offers a base salary typically between $145,000 - $150,000. There is an opportunity to consider higher compensation above this range based on business need, candidate experience, and or skills.

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