Senior Scientist - LNP Quality Control Testing

Work Schedule

Environmental Conditions

Job Description

At Thermo Fisher Scientific, youll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on now and in the future.

Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission to enable our customers to make the world healthier, safer, and cleaner.

Within our Analytical Services team, we have a functional service provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.

The LNP Quality Control & Sample Testing Contractor should be adept at the execution and interpretation of data generated by quality control assays for lipid-based nanoparticles (LNPs) to facilitate the development of CRISPR-Cas9 based gene editing therapies. This individual will perform a critical role supporting the evaluation and advancement of lead assets for our therapeutic programs. The roles responsibilities include working with a cross-functional team of synthetic chemists, formulation scientists and analytical scientists to provide consistent and rigorous evaluation of quality metrics for non-viral gene therapies. The ideal candidate is expected to display a high level of commitment and determination, to complete work in an efficient and proactive manner, and to ensure robust documentation of results to achieve the projected goals in a timely manner.

• Execute industry standard assays to evaluate quality metrics for nucleic acids and LNPs, including sizing, PDI, and encapsulation efficiency
• Ensure rigorous, robust and systematic data collection
• Communicate efficiently with integrated team members to ensure timely sample processing and data reporting
• Maintain exceptional standards for all laboratory records, electronic database entries, internal reports, patents and external communications from the group
• Effectively collaborate with a fully integrated team to facilitate the success of projects

• Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar
• Sr. Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4+ years)
• OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years)
• OR PhD

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

• Advanced expertise in operation of and data interpretation from DLS-based instruments (ie. Malvern Zetasizer, Unchained Labs Stunner)
• Significant hands-on experience in sizing, PDI and encapsulation efficiency analysis
• Comprehensive understanding and hands-on experience with in vitro assays for nucleic acid and LNP analysis
• Experience with liquid handling automation is a strong plus
• Ability to adapt to increasing scope and complexity of work
• Exceptional documentation skills and adherence to policies for data recording and reporting
• Excellent communication skills with the proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team

Below is listed the working environment/requirements for this role:

Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.

Able to work upright and stationary and/or standing for typical working hours.

Able to lift and move objects up to 25 pounds

Able to work in non-traditional work environments.

Able to use and learn standard office equipment and technology with

proficiency.

May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.

Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!