Principal Scientist, Translational Sciences-Immunology

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at

**Job Function:**

Discovery & Pre-Clinical/Clinical Development

**Job Sub** **Function:**

Translational Discovery & Development Biomarkers

**Job Category:**

Scientific/Technology

**All Job Posting Locations:**

Spring House, Pennsylvania, United States of America

**Job Description:**

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

About Immunology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

We are searching for the best talent for a Principal Scientist, Translational Science Immunology to be located in Spring House, Pennsylvania.

As Immunology Leaders, we know immunology is vital to human health. Driven by a relentless focus on patient unmet needs, we will redefine treatments for immune diseases by delivering transformational and accessible therapies and regimens to patients with immune-mediated disease. For more than two decades we have been a world leader in the development of transformational medicines, establishing one of the strongest, first-in-class portfolios and pipelines in the industry, including the first tumor necrosis factor (TNF) inhibitor, and first interleukin (IL)-12 and IL-23 inhibitors. We tirelessly push the boundaries of science and creativity, applying our deep disease insights, novel pathway science, new technologies, and treatment modalities to restore immune homeostasis.

The Translational Science group (TS) has the primary responsibility for creating and implementing innovative translational plans for portfolio assets. TS is a group within the Immunology Therapeutic Area consisting of a Translational Science and Translational Medicine (TM) teams that form the Translational Science and Medicine department (TSM). TS has combined expertise in developing asset specific and disease specific biomarkers from conception, assay development and implementation into clinical studies to study and drive biological understanding of immunologic disease and immunologic pathways. Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of

novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases.

This position is within the Immunology Translational Sciences group and requires a highly motivated and skilled candidate to drive the translational research of innovative therapies across immune-mediated diseases. The Principal Scientist will provide biomarker support for Immunology clinical programs with a focus on maternal fetal immunology and rare diseases. The successful candidate will lead a matrixed team with diverse expertise in assay development and translational research. Key activities include leading biomarker discovery efforts, assay development and assay validation (including but not limited to flow cytometry assays), organizational excellence, and laboratory supervision. The successful candidate will utilize a full suite of advanced technologies to enable cutting edge research. Furthermore, the candidate will partner with cross-functional teams to engage in interactions with external experts, commercial vendors, and academic institutions to advance Immunology portfolio

**Responsibilities are as follows:**

+ Oversee the design and execution of translational science and biomarker plans integrating both disease and pathway approaches to support portfolio programs

+ Drive operational efficiency for translational biomarker implementation, including engagement with external vendors and academic partners

+ Contribute to the strategies on molecular understanding of human diseases, patient stratification and biomarker-based endpoint translational strategies

+ Guide team members in the communication of study results and guide stakeholders in applying those results to making strategic decisions

+ Work closely with key leaders in partner functions to ensure project goals are met

+ Represent TS on program discovery and development teams

+ Contribute to the overall departments strategic direction with special focus on increasing the impact of translational science approaches in drug discovery and development

+ Lead internal and external collaborations to increase team capabilities or address a strategic need

+ Take initiative to identify, pilot and internalize emerging technical approaches that may drive increased value for portfolio execution

+ Help build an extensive external network of leaders in Immunology to enable strategic partnerships and awareness of advances in translational and biomarker research

+ Prepare and/or direct the preparation and review of protocols, clinical study reports and translational science sections of Translational plans, IBs, INDs, abstracts, manuscripts, and technical reports

**Qualifications:**

+ PhD or MD/PhD in immunology or a related field with at least 5 years of relevant experience is required, preferably in pharmaceutical or biotechnology sectors

+ Training in rheumatology or experience with translational research in rheumatological diseases is strongly preferred

+ Experience in translational research, including biomarker analysis, patient stratification, and diagnostic approaches, in the industry setting is strongly preferred

+ Project leadership experience in a matrixed environment is strongly preferred

+ Experience gaining biological insights using translational and biomarker high-dimensional biological data (e.g., transcriptomics, genomics, proteomics) is preferred

+ Strong communication skills and the ability to effectively navigate and prioritize in a dynamic work environment are required

+ Willingness and ability to travel (up to ~10%) is required

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (...) or contact AskGS to be directed to your accommodation resource.

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