PBPK Modeling - Senior Scientist
Employer
Takeda
Location
Boston, Massachusetts
Start date
Jul 26, 2025
categoriesView less categories
Job Details
Company
Job Details
By clicking the Apply button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
Objective / Purpose:.
The Global Drug Metabolism, Pharmacokinetics and Modeling (DMPK&M) department at Takeda is seeking a strong candidate to be a part of the Physiologically Based Pharmacokinetic (PBPK) modeling team for supporting drug-drug interaction (DDI) and PK prediction in Takeda's global research and development pipeline for all therapeutic areas
The candidate is expected to have demonstrated experience in conducting PBPK modeling using Simcyp, Gastroplus, PKSim or other relevant software
Accountabilities:
A successful candidate will be responsible for the design and implementation of PBPK models for small molecules and biotherapeutics supporting discovery and development programs. The accountabilities of this role include but are not limited to -
Develop the PBPK framework for preclinical species and humans in Simcyp, Gastroplus, Matlab, Phoenix or other relevant software
Apply the models to new chemical entities for understanding tissue distribution to inform drug-target coverage and safety margins, predicting absorption and PK, and evaluating the impact of drug-drug interactions
Predict PK in special populations (e.g. hepatic or renal impairment patients, pediatrics, pregnant population, diseased population, etc.)
As required, develop novel PBPK models to answer mechanistic questions.
Collaborate with multi-functional project teams and functional group colleagues to identify data requirements for model development, and strategies for model application and use.
Education & Competencies (Technical and Behavioral):
PhD degree with 3+ years relevant experience, Or MS with 9+ years relevant experience, or BS with 11+ years relevant experience in Pharmaceutical Sciences, Drug Metabolism and Pharmacokinetics, Pharmacology or other relevant field
Strong understanding of the concepts of, and prior experience in PBPK modeling
Strong training and understanding of the concepts of drug metabolism and pharmacokinetics of diverse modalities (e.g. small molecules, biotherapeutics), biochemical aspects of drug metabolism enzymes and transporters, and various in vitro assays conducted to assess DDI potential
Proficient in one or more of the following modeling and simulation software - Simcyp, Gastroplus, PK-Sim, Matlab and/or Simbiology, R, Phoenix, Berkley Madonna, ADAPT, Mathematica or other relevant software
Track record of publication and / or conference presentations
Exceptional interpersonal, verbal communication and writing skills
Good organizational and planning skills
Provenrecord of accomplishmentof teamwork, adaptability, innovation,initiative,and integrity
Strong quantitative, analytical and problem-solving skills
Global mindset to grow in a diverse work environment
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Base Salary Range:
$137,000.00 - $215,270.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployee
Worker Sub-TypeRegular
Time TypeFull time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Company
For over 240 years, Takeda's propensity to evolve has driven the next generation of innovation. Today, our organization spans the globecolleagues across business units and functions face challenges head-on to deliver life-transforming treatments, guided by our commitment to patients, our people and the planet.
As a values-based, R D-driven biopharmaceutical leader headquartered in Japan, we focus our R D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R D investments in Plasma-Derived Therapies and Vaccines. In addition to our R D efforts, we're laser-focused on harnessing the power of data, digital, and technology to improve health outcomes for patients across the globe.
Since our founding in Japan, integrity and putting patients first have been at the heart of our identity. We're proud of our employees and their commitment to improving the quality of life for patients, and to working with our partners in health care in approximately 80 countries and regions. With each new breakthrough comes opportunities to develop your career, hone new skills, and create a brighter future
For more information, visit jobs.takeda/
Company info
Employer
Takeda
Location
Boston, Massachusetts
Start date
Jul 26, 2025
categoriesView less categories
Job Details
Company
Job Details
By clicking the Apply button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda'sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
Objective / Purpose:.
The Global Drug Metabolism, Pharmacokinetics and Modeling (DMPK&M) department at Takeda is seeking a strong candidate to be a part of the Physiologically Based Pharmacokinetic (PBPK) modeling team for supporting drug-drug interaction (DDI) and PK prediction in Takeda's global research and development pipeline for all therapeutic areas
The candidate is expected to have demonstrated experience in conducting PBPK modeling using Simcyp, Gastroplus, PKSim or other relevant software
Accountabilities:
A successful candidate will be responsible for the design and implementation of PBPK models for small molecules and biotherapeutics supporting discovery and development programs. The accountabilities of this role include but are not limited to -
Develop the PBPK framework for preclinical species and humans in Simcyp, Gastroplus, Matlab, Phoenix or other relevant software
Apply the models to new chemical entities for understanding tissue distribution to inform drug-target coverage and safety margins, predicting absorption and PK, and evaluating the impact of drug-drug interactions
Predict PK in special populations (e.g. hepatic or renal impairment patients, pediatrics, pregnant population, diseased population, etc.)
As required, develop novel PBPK models to answer mechanistic questions.
Collaborate with multi-functional project teams and functional group colleagues to identify data requirements for model development, and strategies for model application and use.
Education & Competencies (Technical and Behavioral):
PhD degree with 3+ years relevant experience, Or MS with 9+ years relevant experience, or BS with 11+ years relevant experience in Pharmaceutical Sciences, Drug Metabolism and Pharmacokinetics, Pharmacology or other relevant field
Strong understanding of the concepts of, and prior experience in PBPK modeling
Strong training and understanding of the concepts of drug metabolism and pharmacokinetics of diverse modalities (e.g. small molecules, biotherapeutics), biochemical aspects of drug metabolism enzymes and transporters, and various in vitro assays conducted to assess DDI potential
Proficient in one or more of the following modeling and simulation software - Simcyp, Gastroplus, PK-Sim, Matlab and/or Simbiology, R, Phoenix, Berkley Madonna, ADAPT, Mathematica or other relevant software
Track record of publication and / or conference presentations
Exceptional interpersonal, verbal communication and writing skills
Good organizational and planning skills
Provenrecord of accomplishmentof teamwork, adaptability, innovation,initiative,and integrity
Strong quantitative, analytical and problem-solving skills
Global mindset to grow in a diverse work environment
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Boston, MA
U.S. Base Salary Range:
$137,000.00 - $215,270.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployee
Worker Sub-TypeRegular
Time TypeFull time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Company
For over 240 years, Takeda's propensity to evolve has driven the next generation of innovation. Today, our organization spans the globecolleagues across business units and functions face challenges head-on to deliver life-transforming treatments, guided by our commitment to patients, our people and the planet.
As a values-based, R D-driven biopharmaceutical leader headquartered in Japan, we focus our R D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R D investments in Plasma-Derived Therapies and Vaccines. In addition to our R D efforts, we're laser-focused on harnessing the power of data, digital, and technology to improve health outcomes for patients across the globe.
Since our founding in Japan, integrity and putting patients first have been at the heart of our identity. We're proud of our employees and their commitment to improving the quality of life for patients, and to working with our partners in health care in approximately 80 countries and regions. With each new breakthrough comes opportunities to develop your career, hone new skills, and create a brighter future
For more information, visit jobs.takeda/
Company info
Job ID: 487121863
Originally Posted on: 7/28/2025
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