Scientist, Product Development Early Stage (#YC-1112)

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X and Facebook . ( *in collaboration with AbbVie )

About the Role:

Work with the Chemistry, Manufacturing, and Controls (CMC) project team to contribute and participate in early discovery through Phase 2a.

Provide formulation and analytical support for multiple preclinical programs.

Execute pre-formulation and preclinical formation development studies to support product advancement from early discovery through commercial.

Support the Product Development team through the following studies: thermodynamic and kinetic solubility, in-use stability, dose verification, toxicology formation development, high performance liquid chromatography (HPLC) method optimization and fit-for-purpose development, and other lead drug development candidates.

Prepare and evaluate formulations for administration in preclinical studies.

Perform chemical and physical stability studies focused on aqueous, organic, thermal and photo degradation.

Present drug development updates during department meetings, prepare author memorandums/reports, and deliver pharmaceutical talks on current and new techniques in support of early product development.

Source, procure, install, qualify, operate, and maintain instrumentation and pharmaceutical equipment required for pre-formulation and material science.

Participate in weekly and bi-weekly Product Development team meetings and report drug development progress, resource gaps, and timelines.

Design and conduct developability assessment of novel peptide therapeutics to enable the selection of a development compound. Support the PD-DDTC (Product Development Drug Delivery Technology Center) and PD-LS (Product Development Late Stage) teams in the formulation development and characterization of injectable/parenteral peptides.

Design and conduct studies to support scale up during formulation development of peptides/mAbs.

Collaborate with the Discovery team for batch characterization to release Gene Therapy test articles for non-GLP (Good Laboratory Practices) and GLP use.

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Requirements:

• Bachelors degree or equivalent in Chemistry, Biochemistry, Chemical Engineering, or a related field.

• 2 years of experience in the field of pharmaceutical industry in a chemistry, analytical, or characterization laboratory setting.

• Employer will accept a Masters degree or equivalent in Chemistry, Biochemistry, Chemical Engineering, or a related field in lieu of a Bachelors degree or equivalent and 2 years of experience in the field of pharmaceutical industry in a chemistry, analytical, or characterization laboratory setting.

• Work experience to include: (1) Scientific principles, methods, and techniques, including solubility determination, physiochemical characterization of small molecules and biologic modalities, and developability profiling for compound selection (small molecules and biologics). (2) Project management. (3) Current Good Manufacturing Practices (cGMPs) relating to early drug product manufacturing. (4) Physical and analytical techniques. (5) Developing and executing chemical and instrumental methods (including DLS, Viscometer, Osmometer, Endotoxin, HCP ELISA, dPCR, ddPCR, HPLC, Solubility Analysis, DSC, TGA, PXRD, Particle-Size Analysis, GVS, PLM, and SEM) of analyses for development compounds, drug substances, raw materials, intermediates, drug products, and packaging materials.

• 40 hrs./wk.

• Salary: $88,000 to $140,800/yr.

• Address of employment: Neurocrine Biosciences, Inc. located at 6027 Edgewood Bend Court, San Diego, CA 92130.

How to Apply:

Individuals interested in applying for this position must email resumes to Neurocrine Biosciences, Inc. at talent@neurocrine.com referencing Job #YC-1112, or mail resumes to Neurocrine Biosciences, Inc., Attn: Elina Yapparova, Job #YC-1112, 6027 Edgewood Bend Court, San Diego, CA 92130.

Neurocrine Biosciences, Inc. is an EEO/AA/Disability/Vets employer.

Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment , and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications dont line up to exactly what we have outlined in the job description.

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