Senior Staff Scientist

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the worlds leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the worlds deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems.

The Thomas lab in the Vaccine and Infectious Disease Division is seeking a Senior Staff Scientist for its immune repertoire profiling program.

The individual will be responsible for a) sample selection and study design, b) experimental protocols for data generation, and c) data analysis specifically for lymphocyte TCR and BCR repertoire sequencing. Studies will be focused on primary human samples derived from blood or tissues in individuals with characterized infection or tumor histories. Using a combination of bioinformatic and computational approaches, we will integrate these data with other data and metadata obtained from the sample and individuals, including tumor mutation profiles, infection histories, serology, and other high resolution immune profiling. In addition to these core objectives, we will include analysis of valuable and clinically relevant sample sets such as HCT patients experiencing GVH, and aplastic anemia subjects.

In this position, the incumbent will develop novel TCR/BCR repertoire sequencing technologies for tumor-infiltrating lymphocytes.

Responsibilities

• Conduct experiments/projects independently under overall direction of the research team lead.
• Develop new research protocols, techniques, and procedures for isolating and expanding tumor infiltrating lymphocytes, high-throughput sequencing and molecular cloning of TCR genes and screening of TCRs against potential neoantigens.
• Identify, process, organize, interpret, review and report relevant experimental data.
• Monitor data collection and entry methods to meet quality standards.
• Present research to colleagues within and outside the institution; publish as co-author and draft sections of research manuscripts.
• Guide optimal lab operations.
• Regularly train and oversee the work of others in laboratory techniques and procedures.
• Other duties as assigned.

Qualifications

MINIMUM QUALIFICATIONS:

• PhD with 6+ years of relevant experience.
• Proven performance in a comparable role.
• Experience in High Throughput Sequencing (HTS) library preparation protocol development and optimization, molecular cloning and mammalian tissue culture.
• Experience in molecular biology, high-throughput sequencing library preparation, cancer biology and tumor infiltrating lymphocytes.

PREFERRED QUALIFICATIONS:

• Experience in immune repertoire sequencing.
• Experience working with relevant lab protocols.
• Prior experience in molecular biology/genomics/cancer biology/high-throughput sequencing.
• Well organized with strong attention to detail.

The annual base salary range for this position is from $94,037 to $212,035, and pay offered will be based on experience and qualifications.

This position may be eligible for relocation assistance. Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (up to 13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 12 months for professor track faculty, up to 6 months for other scientific staff).

Additional Information We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to Human Resources at ... or by calling ....