Clinical Diagnostics Laboratory Scientist

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Were looking for people who are determined to make life better for people around the world.

Organization Overview:

The Clinical Diagnostics Laboratory (CDL) comprises several complementary and strategically aligned research teams led by a diverse group of pathologists, scientists, and technicians who collaborate to enhance the technical success of Lilly assets. As a CAP accredited, CLIA pathology laboratory, the CDL accomplishes this by implementing novel biomarker assays that are used to determine pharmacodynamic response, prognostic value, or utility for patient stratification using specimens from Lilly clinical trials. A core mission of the CDL is to employ both standardized and emerging laboratory technologies to characterize disease on translational cohorts using blood- and tissue-based biomarkers related to the drug target and mechanism of action. These fundamental insights are translated into targeted therapeutic and biomarker hypotheses that can be tested in clinical trials and used to drive drug development.

Responsibilities:
The laboratory is looking to welcome a scientist to join CDL teams to investigate the underlying molecular basis of diseases, aligned with the current portfolio in immunology, neurodegeneration, and other key areas. The successful candidate will design, conduct, and report experiments within a collaborative environment, applying a repertoire of standardized and custom clinical laboratory techniques. The scientist will curate metadata using data standards and collaborate with pathologists and senior scientists to interpret new data, employing advanced analytical methods. For technical and professional development, CDL scientists contribute to evaluations of emerging technologies and have access to scientific/technical specialty groups within Lilly and its external partnerships.

• Techniques. Standardized and emerging clinical laboratory techniques are used to assess both proteins and nucleic acids in samples derived from tissue biopsies or blood collection. The scientist may perform isolation and quantitation procedures (protein, nucleic acids, extracellular vesicles), qPCR, dPCR, NGS/RNA-Seq, flow cytometry, ELISA, IP/enrichment, in situ hybridization, immunofluorescence, immunoblotting, laser capture microdissection (LCM), digital imaging and database updates, or other pathology methods. Routine methods are performed as outlined in approved SOPs or as outlined in experimental plans for novel approaches.
• Emerging technology and assay development. This role focuses initially on developing novel plasma and tissue sample enrichment methods, such as LCM or vesicle isolation, that have potential for incorporation into established clinical assay workflows. The scientist participates in related novel molecular assay development or validation.
• Data Analysis and Metadata. The scientist collaborates with pathologists and senior scientists to 1) interpret datasets to derive biological insights, summarize outcomes; 2) gain experience managing large clinical sample datasets including proficiency with LIMS and data repositories; 3) follow or customize sample tracking procedures; and 4) participate in digital sample management activities.
• Technical Communication. The scientist is responsible for authoring project plans, standard laboratory procedures, and contemporaneously documenting experiments, data, technical reports, and findings electronically. The scientist delivers data to various groups and contributes to group reports, regulatory documents, posters, and manuscripts. CDL scientists may communicate with both internal and external partners and present data to support decisions in cross-functional teams.
• Quality. The scientist must understand and apply regulatory expectations for analytical method development, validation, and execution of assays. CDL scientists should adhere to CDL SOPs including CAP/CLIA guidelines when applicable.

Basic Requirements:

• Bachelors Degree in Biochemistry, Biology, Translational Biosciences, Biomedical Engineering, or similar discipline
• 1-2 years of relevant laboratory experience

Additional Skills/Preferences:

• Proficient in plasma preparation, and isolation of plasma nucleic acid and vesicles

• Experience with isolation workflows using formalin-fixed paraffin-embedded (FFPE) tissue samples

• Experience with flow cytometry

• Experience in tissue-based assay development and digital image analysis

• Experience with computational and statistical tools related to techniques of interest

• Experience working in a regulated laboratory

• Demonstrated expertise in experimental design execution and creative problem-solving

• Sustained commitment to contribute to Lilly and CDL team culture and able to work in a fast-paced, collaborative environment on various projects in parallel, independently, or as a group

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Womens Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidates education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lillys compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly