Temp Senior Research Associate, Assay Technologies, Lead Discovery

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for an experienced Senior Research Associate to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of biochemical and biophysical screening techniques to drive the efficient identification and rapid development of clinically impactful drugs against frontier targets in oncology. Working from the bench, they will apply their biochemical and biophysical expertise. The candidate will support Discovery Science efforts to enhance how we discover inhibitors of established and new drug target proteins, as well as contribute to our mission of providing high-quality experimental data for existing programs.

Responsibilities:

• Design and execution of lead discovery screening methods and experiments to identify compound hits and advance them through hit-to-lead and lead optimization stages.

• Collaborate within Discovery Science and cross-functionally with Compound Management, Structural Biology, and Biology/Chemistry teams to develop and implement biochemical and biophysical assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development.

• Develop, characterize, and execute novel biochemical and biophysical assays to support screening and preclinical development.

• Communicate scientific progress effectively to Discovery Sciences team and facilitate project execution within established timelines.

• Generate, manage, evaluate, and maintain critical data in an organized manner and disseminate data broadly to relevant departments.

• Maintain detailed electronic lab notebook entries, draft protocols for experiments, assay data summaries, and manage reagent stocks.

Required Skills, Experience and Education:

• Bachelor's degree with 2-5 years of experience or Master's degree with 0-3 years of experience in biochemistry, biophysics, biotechnology, or related field.

• Hands-on protein biochemistry experience (e.g., characterizing and analyzing protein-ligand or protein-protein interactions).

• Experience with biochemical/biophysical assay development, validation, and troubleshooting.

• Proficiency in execution of in vitro biochemical and biophysical assays suitable for the discovery, validation, or mechanistic characterization of target molecules (ITC, SPR/BLI, TR-FRET, fluorescence polarization, etc.)

• Familiarity with data processing and visualization tools for data analysis and figure generation (e.g., R, Vortex, GraphPad Prism, Genedata Screener, etc).

• Attention to detail with excellent organizational, experimental data recording, and time management skills.

• Excellent written and verbal communication skills.

• Innovative and flexible team-player with high energy and a demonstrated willingness to learn in a fast-paced environment.

Preferred Skills:

• Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito, Agilent Bravo, Tecan).

• Experience with high throughput screening.

• Facile with instrumentation, able to trouble shoot problems and work with engineers to generate successful solutions to technical limitations.

• Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.

This is a contract position that will be employed through a third-party recruiting agency. The agency will provide the pay range, which will be based on several factors, including job-related skills, experience, market conditions, and relevant education or training.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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