Temp Senior Research Associate, Chemical Biology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines' Cancer Biology group is looking for a talented senior research associate with a strong background in molecular, cancer and cell biology to support early target discovery, screening, and validation efforts for novel oncology programs. The successful applicant will join the Chemical Biology team within Discovery Biology. They will work closely with scientists and utilize a wide array of cellular, and molecular biology assay and develop reagents to support validation of novel targets for RevMed's unique molecular glue platform. The ideal candidate will have hands-on experience with mammalian cell culture and standard molecular biology techniques. They will participate in engineering new cell models, and develop, optimize, and troubleshoot cellular assays. Above all, we are looking for a highly motivated and driven team player to join our diverse and talented team of scientists at RevMed.

Responsibilities:

• Design and conduct in vitro cellular assays (e.g. mammalian cell culture, Lentiviral Transduction, 2D and 3D cell culture, SDS-PAGE/Western blot, qPCR, CRISPR-based gene editing) and implement relevant assay readout technologies (e.g. Luciferase, CellTiter-Glo, TR-FRET/BRET, MSD).

• Engineer cell lines and establish cellular assay models.

• Maintain cultures of multiple cancer cell lines to support experimental efforts.

• Generate high quality data in a timely manner and maintain detailed experimental records.

• Work with project scientists to process and analyze data and design new experiments.

• Regularly and effectively communicate findings at group meetings.

Required Skills, Experience and Education:

• Bachelor's degree or Master's degree in molecular biology, biochemistry, biotechnology, or related field.

• 5+ years of experience in a cell biology/molecular biology role.

• Extensive experience with mammalian cell culture techniques and manipulation of cells, including excellent aseptic technique.

• Experience in microplate-based assay systems and operation of plate readers or microscopes.

• Highly organized, with excellent record-keeping, problem-solving, and written/verbal communication skills.

• An energetic and proactive team player with the ability to work efficiently in a dynamic company environment.

Preferred Skills:

• Viral transduction and CRISPR/Cas9 gene editing experience.

• Familiarity with data processing and visualization tools for data analysis (e.g. GraphPad Prism) is preferred.

• Experience with automated liquid handling systems and workflows is preferred.

• Familiarity with cellular and biochemical readouts including immunofluorescence, luminescence, cell viability, NanoBRET, ELISA, MSD, and flow cytometry is preferred.

This is a contract position that will be employed through a third-party recruiting agency. The agency will provide the pay range, which will be based on several factors, including job-related skills, experience, market conditions, and relevant education or training.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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