Scientist I - MSAT (Cell & Gene Therapy)

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Scientist I - MSAT (Cell & Gene Therapy) as part of the Manufacturing Technology team based in Somerset, NJ.

Role Overview

We are seeking a motivated Scientist I to join our MSAT team, supporting the development, troubleshooting, and optimization of automated manufacturing processes for CAR-T and other cell therapy products. Under the guidance of senior staff, this role will perform bio-pilot run experiments, technology evaluations, and process improvement studies. The position will directly contribute to manufacturing robustness and efficiency by executing laboratory work, assisting in equipment testing, and analyzing process data.

Key Responsibilities

• Execute bench-scale experiments for bio-pilot run comparisons, technology evaluations, and process improvement initiatives.
• Operate and assist in troubleshooting closed-system and automated platforms (e.g., Prodigy, Rotea, Cue, Lovo, G-Rex).
• Perform and interpret analytical assays, including flow cytometry, qPCR, ELISA, and other cell-based methods, to support process evaluation and comparability.
• Collect, analyze, and summarize experimental data (cell growth, viability, metabolite trends) using statistical tools.
• Support preparation of study protocols, technical reports, and SOPs in compliance with GMP standards.
• Assist in process troubleshooting and root-cause investigations for manufacturing and automation systems.
• Maintain a safe, organized, and compliant laboratory workspace.
• The role makes independent decisions regarding routine laboratory execution, minor troubleshooting, and data analysis within approved study protocols. Guidance is sought from senior team members for experimental design, major troubleshooting steps, and changes to validated processes.

Requirements

• Bachelor's degree in biotechnology, Bioengineering, Molecular Biology, or related discipline
• 2-4 years' experience in cell culture (T-cells, immune cells, or primary cells) in an academic, process development, or GMP environment.
• Hands-on experience with aseptic technique and biosafety cabinet work.
• Exposure to closed-system or automated manufacturing platforms preferred (e.g., Prodigy, Rotea, Cue, Lovo).
• Hands-on experience with analytical assays (flow cytometry, qPCR, ELISA) in a cell therapy, immunology, or bioprocess setting.
• Experience in basic analytical methods such as cell counting, viability assays, and metabolite monitoring.
• Familiarity with data analysis and preparation of technical documentation.
• Proficiency with Microsoft Office (Excel, Word, PowerPoint).
• Basic data analysis using Excel, JMP, or similar tools.
• Ability to interface with instrument control software.

#Li-BZ1

#Li-Hybrid

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.