Principal Scientist Jobs in California
A Principal Scientist in the chemistry industry is responsible for conducting complex research, developing new procedures, and overseeing a team of scientists to ensure all projects are completed to a high standard. They typically perform experimental tests and analyses, interpreting and presenting results, and preparing research reports and scientific papers. Their work is instrumental in contributing to the development of new products, technologies, or intellectual property. They often work closely with other departments such as Regulatory Affairs, Quality Control, and Manufacturing to ensure all scientific operations meet the necessary standards and regulations.
Important skills for a Principal Scientist include leadership, excellent written and oral communication abilities, strong analytical skills, and the ability to work well in teams. They should have a thorough understanding of various scientific techniques and principles, and be adept at problem-solving. The minimum requirement for this position is typically a PhD in Chemistry or a related field, with substantial experience in the industry. Certifications that can add value include Certified Professional Chemist (CPC) or Certified Clinical Research Professional (CCRP). A person might work as a Research Scientist, Senior Scientist, or Project Leader before moving into the role of a Principal Scientist.
The Principal Scientist serves as a subject matter expert and technical leader, driving innovation and high-impact research and development initiatives across dental chemical consumables....
In PersonPrincipal Scientist Lead Discovery and Targeted Protein Degradation Biochemistry
- Amgen
- Thousand Oaks, CA
- 16 hours ago
- Thousand Oaks, CA
- 16 hours ago
Principal Scientist Lead Discovery and Targeted Protein Degradation Biochemistry What you will do Lets do this. Lets change the world....
In PersonMSAT Associate Principal Scientist - Purification
- Lonza
- Vacaville, CA
- 1 day ago
- Vacaville, CA
- 1 day ago
Location: Vacaville, California This is a fully sitebased role. Working together in person supports close, realtime collaboration and the technical precision needed to manufacture medicines to the...
In PersonAssociate Principal Scientist, Respiratory Discovery
- Merck Company
- South San Francisco, CA
- 1 day ago
- South San Francisco, CA
- 1 day ago
We are seeking an Associate Principal Scientist with strong expertise in respiratory biology and translational research to contribute to target discovery, validation, and translational biology strategy...
In PersonSenior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational Medicine
- Bristol Myers Squibb
- Brisbane, CA
- 1 day ago
- Brisbane, CA
- 1 day ago
R1601688 : Senior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational Medicine...
HybridPrincipal Scientist, Protein Sciences, Analytical Characterizations
- Valid8 Financial, Inc.
- San Francisco, CA
- 2 days ago
- San Francisco, CA
- 2 days ago
Principal Scientist, Protein Sciences, Analytical Characterizations September 2025 Department: Technology Position Summary: TCG Labs-Soleil is seeking a highly experienced and driven Principal Scientist...
In PersonPrincipal Scientist/Associate Director, Proteomics (On-Site)
- Neomorph
- San Diego, CA
- 2 days ago
- San Diego, CA
- 2 days ago
The successful candidate will combine deep technical expertise in modern LC-MS proteomics with a strong understanding of assay development, quantitative rigor, and platform growth....
In PersonPrincipal Scientist, Computational Chemistry
- Eikon Therapeutics, Inc.
- Millbrae, CA
- 4 days ago
- Millbrae, CA
- 4 days ago
Position We seek a Principal Scientist in Computational Chemistry with a demonstrated ability of successfully applying in silico technologies to drive the discovery of quality lead-like molecules against...
In PersonPrincipal Scientist, Pharmaceutical Development
- Neurocrine
- San Diego, CA
- 5 days ago
- San Diego, CA
- 5 days ago
Who We Are: Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and...
In PersonPrincipal Scientist, Analytical Development
- Neurocrine
- San Diego, CA
- 5 days ago
- San Diego, CA
- 5 days ago
Experience in method transfer in Analytical Chemistry OR MS/MA in Analytical Chemistry or related discipline and 10+ years of experience OR PhD in Analytical Chemistry or related discipline and 4+ years...
In PersonPrincipal Scientist, Analytical Ops
- Gilead Sciences
- Oceanside, CA
- 5 days ago
- Oceanside, CA
- 5 days ago
Job Description Principal Scientist in Biologics Analytical Development (Pivotal and Commercial)....
In PersonPrincipal Scientist, Amazon Health Science & Analytics
- Amazon.com Services LLC
- Santa Clara, CA
- 5 days ago
- Santa Clara, CA
- 5 days ago
We are looking for a senior AI/ML researcher who can architect and guide a long-horizon ML strategy for a healthcare-focused organization building a durable, domain-specific healthcare foundation...
In PersonProcess Development Principal Scientist
- Amgen
- Thousand Oaks, CA
- 5 days ago
- Thousand Oaks, CA
- 5 days ago
Chromatography and related separation techniques including RP-HPLC (reversed phase high-performance liquid chromatography) and GC (gas chromatography); 5....
HybridAbout this Role Our pharmaceutical R&D team is looking for a highly motivated and creative Principal Scientist, Analytical Sciences who will lead efforts in improving therapeutics with microgravity....
In PersonPrincipal Scientist, Purification Process Development
- Denali Therapeutics
- South San Francisco, CA
- 6 days ago
- South San Francisco, CA
- 6 days ago
Design and execute lab-scale chromatography and filtration studies to inform and support large scale process decisions Maintain existing workflows to provide purification support for cell line and cell...
In PersonDemographic Data for California
Moving to California? Find some basic demographic data about California below.
Principal Scientist Online Courses and Training Opportunities
Title Synonyms
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Salary for Principal Scientist Jobs in California
Required or preferred licenses and certifications for Principal Scientist positions.
Highest Education Level
Principal Scientists in California offer the following education backgroundQualifications / Skill Sets
The following top skills are often required or desired to land a Principal Scientist position
- Personal Protective Equipment
- Chromatography
- Method Development
- Liquid Chromatography
- High-Performance Liquid Chromatography
- Analytical Chemistry
- Assay Development
- Scale-Up
- Rheology
- Purification
- Analytical Method Transfer
- Liquid Chromatography Mass Spectrometry
- Medicinal Chemistry
- Cell-Based Assays
- Cell Biology
- Biomarkers
- Proteomics
- Dynamic Light Scattering
- Peptide Synthesis
- Mass Spectrometry
- Clinical Laboratory Operations
- Chemical Characterization
- ICP-MS
- Biochemistry
- Fourier Transform Infrared Spectroscopy
- Organic Chemistry
- Drug Development
- Ultra Performance Liquid Chromatography
- Drug Discovery
- Experimental Design
- Cell Culture
- Molecular Biology
- Toxicology
- Immunology
- Laboratory Management
- Research and Development
- Validation
- Biotechnology
- Biology
- Optimization
- Process Development
- Clinical Trials
- Good Manufacturing Practices
- Hazardous Materials
- Oncology
- Modeling
- Standard Operating Procedures
- Product Development
- Engineering
- Quality Control
- Troubleshooting
- Investigation
- Documentation
- Quality Assurance
- Mentoring
- Implementation
- Reporting
- Data Analysis
- Collaboration
- Education Experience
- Bachelor's Degree
- Regulations
- Research Skills
- Staff Supervision
- Problem Solving
- Scheduling
- Leadership
- Communication Skills
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