Manager, Scientist, Innovative CT Processing

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

Job Summary:

We are seeking a scientist to design and develop adaptive control schema to advance next generation cell therapy manufacturing. The primary responsibilities of this role are to support the development of mechanistic understanding of process, drug product, and clinical outcome and identify processing strategies to control product attributes during the manufacturing process. Specifically, this role will support systematic screening of phenotypic attributes, process additives and culture conditions and characterization of CAR T drug product attributes response to perturbation towards the definition of a robust adaptive process control schema that will be implemented in manufacturing workflows. This role provides a unique opportunity to collaborate with a variety of teams within the Cell Therapy Development Organization at BMS and engage in the implementation of innovating processing strategies discovered through this work.

Key Responsibilities

• Support mechanistic model development of cell therapy process and product through high-throughput system perturbation and inhibition experimentation
• Leverage in-process product characterization, product-outcome correlations and causal experimental results to design and execute adaptive control experiments
• Use a wide array of analytical tools to quantify T cell state (flow cytometry, PCR, secreted protein quantification)
• Perform analysis and interpretation of results with regular presentations to internal working team
• Project Planning including support drafting of technical development activities and projected timeline to achieve desired project goal(s), present project plans to internal stakeholders
• Experiment Planning including conduct literature review, design experiments and propose to relevant stakeholders/subject matter expert for guidance, and maintain inventory, communicate shortages and coordinate procurement of necessary reagents
• Experiment Execution including to coordinate experiment preparation activities for timely execution,. execute proposed experiments and collect desired data, including high-throughput system perturbation and inhibition experimentation, and utilize a wide array of analytical tools to quantify T cell state for in-process product characterization
• Data Analysis and Reporting to analyze experiment data to identify trends, support correlative analysis, and determine next steps, utilize data management tools and data reporting tools to document progress, support mechanistic model development of cell therapy process and product, prepare and present reports on experimental activities and project status
• Collaboration and communication including to work closely with various functions within the cell therapy development organizations to obtain feedback and share knowledge, and communicate effectively with internal stakeholders to ensure alignment and transparency.

Required Qualifications & Experience:

• PhD in immunology, biomedical engineering, cell biology or related discipline
• Previous experience in in vitro culture of primary cells and cell lines
• Experience in molecular and biochemical laboratory techniques applied to cell characterization including flow cytometry, secreted protein quantification and DNA/RNA extraction, PCR
• Proficient in high dimensional data handling and analysis
• Excellent written, verbal and presentation skills
• Highly-motivated, detail-oriented individual with the ability to multitask and collaborate effectively
• At least one first-author publication in peer-reviewed scientific journals.
• Preferred Skills
• Familiarity executing high-throughput screening techniques
• Previous experience analyzing large data through coding languages
• Previous experience with design, development, execution and analysis of in vivo experiments

The starting compensation for this job is a range from $97,000 - $121,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and the geographic location where work is performed. Final, individual compensation is decided commensurate with demonstrated experience. For more on benefits, please visit our BMS Careers Site. Eligibility for specific benefits listed therein may vary based on job and location.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

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