Principle Scientist

We are seeking a highly motivated Principal Scientist within the Formulation Development Group (FDG) of Regeneron Pharmaceutical Inc. at Tarrytown, NY. The Principal Scientist leads formulation and drug product development that may include candidate screening and selection for preclinical and Phase 1 clinical studies, developing formulations for Phase 2/3 clinical studies and commercialization.

A Typical Day in the Role May Look Like:

• Lead formulation and drug product development activities for multiple programs of different modalities, such as peptides, monoclonal antibodies or AAVs, in collaboration with analytical and drug product process development and other cross functional teams.

• Design and conduct biochemical and biophysical characterization and pre-formulation studies to support evaluation of preclinical drug candidates and developing preclinical and FIH formulations

• Independently designs and conducts stability studies and other experiments to support formulation development and stability testing in various phases

• Develops and applies analytical methods to support product characterization, formulation development, and stability testing of peptide, protein based biologics and gene therapy modalities, such as AAV.

• Serve as a program lead and subject matter of experts at the cross functional research, CMC and program teams

• Presents work at group, department and inter-department meetings, and shares knowledge and expertise of formulations development at cross-functional team meetings.

• Authors and reviews formulation development sections of regulatory and technical documents, study reports and technology transfer documents

• Mentors and manages research associates as needed

• Seeks out, recognizes and assesses new technologies to improve formulation development and analytical characterization

• Conducts research (problem solving, characterizing protein stability, etc), presents at external conferences and publish work

This Role May Be for You If:

• You have hands-on experience in peptides, protein, antibodies, AAV, or other gene and cell therapies in a biopharmaceutical setting

• You have strong technical knowledge base and proven experience with biophysical/biochemical characterization, bioanalytical method development or biomolecule product development.

• You have hands-on experience and trouble-shooting proficiency with analytical and characterization techniques for biomolecules, such as column chromatographic (HPLC/UPLC), capillary electrophoresis and/or biophysical techniques (such as DLS, CD, FTIR, DSC, AUC) for protein characterization.

• You have a passion for science with motivation for making contributions and thrive in fast-paced collaborative team environment.

• You are capable of multi-tasking, working both independently and within a collaborative environment.

• You excel when working in a fast-paced environment.

• You have excellent verbal and written communication and organization skills, with a proven track record.

To be considered for this opportunity, you must have the following:

PhD in Chemistry, or Biochemistry, Biophysics, Pharmaceutical Sciences, or a related discipline with minimum 3 years of relevant industry experience. A BS/MS degree and 11+ years relevant experience may also be considered.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$126,700.00 - $206,900.00