Effector Function Scientist Protein Therapeutics

Role Description

The Protein Therapeutics group within Global Therapeutics Research at Zoetis has the mission and responsibility for identifying and delivering novel large and small molecule therapeutics for a diverse array of indications. We are seeking a talented and experienced scientist to support cell-based effector function assays to characterize monoclonal antibody Fc subclasses in veterinary species. The incumbent will also be responsible for cell-based and protein binding assays supporting Parasitology projects. The ideal candidate will have a solid understanding of immunology, monoclonal antibody therapeutics, Fc effector function, antibody/protein binding kinetics, flow cytometry, cell imaging techniques and parasitology. This position will also work collaboratively with teams at remote sites.

The successful candidate will have a B.S (with 3-6 years experience) or M.S (with 2-4 years experience) with an emphasis in Immunology, Cell biology, Molecular biology or related field. Excellent communication, organizational and interpersonal skills are essential.

POSITION RESPONSIBILITIES:

• Design, conduct and interpret data from cell-based effector function assays (CDC, ADCP and ADCC) for veterinary species of interest.
• Design, conduct and interpret data from antibody/protein binding kinetic assays using SPR, mainly Biacore.
• Design and development of cell-based assays using cell imaging techniques
• Design and development of whole blood flow cytometry assays
• Design and development of cell-based assays supporting heartworm target projects.
• Collaborate with and support research teams, CROs and project teams for successful completion of cell-based and SPR assays
• Record experiments and data appropriately and author technical reports
• Keep abreast of relevant new technologies & relevant literature
• Ensure work activities are aligned with data acquisition, notebook entry and EHS requirements.

EDUCATION:

• B.S. (with 3-6 years experience) or M.S (with 0-5 years experience) in Biology, or Cell and Molecular Biology.

PREFERRED SKILLS:

• Extensive experience with cell culture of both cell lines and primary cells, with a strong preference for experience with veterinary species
• Knowledge and working experience handling antibody samples
• Experience with cell killing assays
• Experience with Incucyte live-cell real-time imaging system
• Basic experience with Biacore SPR instrument
• Ability to independently contribute from the bench
• Ability to design and execute various cell-based assays and data analysis/interpretation
• Good oral and written communication skills
• Must be highly motivated. The ability to take direction and work simultaneously on multiple projects is essential.

ADDITIONAL INFORMATION:

Work environment:

The placement of this position will be primarily in Kalamazoo, MI. Occasional travel to other Zoetis sites may also be requested.

The person filling this position will work predominantly in a laboratory setting. There may be exposure to animal pathogens and chemicals. Strict biosafety and biosecurity training will be completed prior to handling animal tissues and zoonotic organisms.

Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.

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