Principal Scientist, Translational Immunology

About This Role Biogen is seeking an experienced Principal Scientist to help drive our biomarker and translational immunology strategies across several therapeutic programs in multiple indications. Translational Immunology at Biogen's West Coast Hub investigates the molecular pathways of disease to build upon our understanding of the mechanism of action of our therapeutics. The role is highly collaborative and will focus on technology development in single cell biology to inform both preclinical and clinical stage therapeutic programs. The successful candidate will be highly motivated, be able to think strategically and creatively, and be able to work independently to investigate novel biology of our therapeutics and their effect on immune cells in the context of severe immune-mediated diseases. This position will report to the Translational Immunology Lead at the Biogen West Coast Hub located in South San Francisco, CA. What You'll Do Lead translational research projects to inform the mechanism of action of our therapeutics and address key evidence gaps Evaluate and build upon state-of-the art single cell technology platforms and lead implementation in translational research projects and clinical studies Independently design experiments, perform laboratory benchwork, analyze and interpret data, and clearly communicate complex results to cross-functional teams within the organization and externally Develop clinically relevant in vitro , ex vivo , and in vivo model systems to interrogate the effect of our therapeutics Contribute to the development of biomarker strategies focused on generation of clinical evidence of immune target/pathway engagement and modulation of disease biomarkers Serve as the subject matter expert on the application of molecular and immunological techniques and model systems to drug development programs and contribute to asset clinical development and biomarker plans Work with cross-functional teams including discovery research, biomarker, clinical, biostatistics, and bioinformatic scientists Contribute to the preparation of study reports and summaries required for primary research publications, patent filings, and/or regulatory documents Participate in conferences and academic partnerships in the primary research area Who You Are You are a creative and inquisitive scientist with strong scientific training in immunology and single cell biology who can lead and drive innovative projects aimed at uncovering novel biology of therapeutics. Required Skills PhD in Immunology or related field with minimum 5+ years of relevant industry experience. BS/MS with 9+ years of relevant industry experience may be considered. Expertise in single cell biology including scRNA-seq, sc immune profiling of BCR/TCR repertoire, CITE-seq, combinatorial indexing, and spatial transcriptomics Knowledge and proficiency in single cell data analysis and visualization using R or Python Expertise in in vitro / ex vivo cell-based techniques including isolation of primary human immune cell subsets, mammalian cell culture, cell-based functional assays and multiparameter flow cytometry (10+ colors) Proficiency in flow cytometry software (FACSDiva, SpectroFlo, FlowJo, etc), GraphPad Prism, and Microsoft Office programs Strong scientific publication record in the field of immunology or related field Excellent oral, presentation, and written communication skills Ability to manage and prioritize multiple projects simultaneously Proven ability to work collaboratively in a team-oriented environment Preferred Skills Strong track record of industry experience in applying immunological techniques to drug development Job Level: Management Additional Information The base compensation range for this role is: $139,000.00-$186,000.00 Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance. In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees' and their families physical, financial, emotional, and social well-being ; including, but not limited to: Medical, Dental, Vision, & Life insurances Fitness & Wellness programs including a fitness reimbursement Short- and Long-Term Disability insurance A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31) Up to 12 company paid holidays + 3 paid days off for Personal Significance 80 hours of sick time per calendar year Paid Maternity and Parental Leave benefit 401(k) program participation with company matched contributions Employee stock purchase plan Tuition reimbursement of up to $10,000 per calendar year Employee Resource Groups participation Why Biogen? We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives. At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts. All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States. PDN-9efc1b12-58fc-4850-a45a-9ee380927c61