Senior Scientist, Statistical Genetics

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

We seek a talented computational researcher to contribute to using large - scale human genetic data . This role will sit within Informatics & Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development within BMS research .

A key focus will be the development of productionized pipelines and scalable workflows to enable genomic analyse s across multiple biobanks . This will involve application of innovat ive statistical genetics methods that combine human genetic data with functional and clinical data (e.g., GWAS, fine-mapping , colocalization, Mendelian Randomization, rare variant associations tests, and polygenic modeling methods) to build and inform therapeutic hypotheses . Additionally, there will be an emphasis on using machine learning techniques and approaches informed by artificial intelligence to generate predictions of clinical success. It will also include synthesizing and communicating key findings to a broad and collaborative research team .

This position offers a n exciting opportunity to impact human health through innovat ive human genomics research , and will enable discovery groups within BMS research to launch novel programs based on causal human biology. It is also an opportunity to work closely with the broader scientific community through pre-competitive collaborations ( e.g. FinnGen , UK Biobank , UK Genes & Health , Alliance for Genomic Discovery ) , and to publish and present industry-leading work in this area .

Location: Cambridge, MA

Responsibilities will include, but are not limited to, the following:

• Develop and deploy productionized and reproducible bioinformatics workflows to perform genomic analyses at biobank scale ( e.g. GWAS meta-analysis, rare variant burden tests)

• Work with a team of scientists who use human genetics and complementary omics data to identify novel targets and develop therapeutic hypotheses for indications of interest across the BMS portfolio .

• Design and perform integrative analyses to infer causal mechanisms driving disease using human genetics and other data types ( e.g. sc-RNAseq )

• Leverage state-of-the-art machine learning and artificial intelligence techniques to generate novel therapeuti c insights and predictions of clinical success

• Coordinate with stakeholders across research to inform drug targets and program strategies with genetic data and causal human biology

• Communicate findings and recommend follow up actions in multiple settings (including 1:1, seminars, project meetings, and external publications)

Basic Qualifications:

• Bachelors Degree with 6 + years of academic / industry experience
• Master's Degree 5+ years of academic / industry
• Or PhD with 2 + years of academic / industry experience

Preferred Qualifications:

• PhD in statistical genetics , population genetics , or a related computational/quantitative discipline field with 2 + or more years of r elevant postdoctoral research and/ or industry experience prefer r ed

• Deep scientific expertise in statistical genetics methods for genetic association studies and exten si ve experience working with biobank scale data

• Advanced knowledge of at least one bioinformatics workflow language e.g., N extflow , WDL, or CWL

• Proficiency in at least one high-level programming language such as R or Python

• Familiarity with applications of machine learning and artificial intelligence to genomic datasets, such as supervised learning methods and large language models (including protein langua ge models)

• Demonstrated ability to advance multi-disciplinary team projects required

The starting compensation for this job is a range from $148,300 - $179,600 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience .

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

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