Senior Scientist, Oncology Discovery Biology

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Responsibilities:

In the role as a Senior Scientist within the Cancer Immunology team, the ideal candidate:

• Proposes and evaluates new target ideas in the Cancer Immunology space.

• Uses current and innovate new techniques for identification and selection of T cell engager (TCE) lead drug candidates.

• Executes experiments independently, troubleshoot as needed, interpret, and discuss data.

• Performs laboratory work related but not limited to tissue culture, multi-parametric flow cytometry, western blot, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex, processing of DNA/RNA/protein.

• Accurate and detailed record-keeping.

• Presents data in project meetings and department meetings.

• Collaborates with rest of biology team members as well as other functional area leads e.g. protein purification, in vivo pharmacology, DMPK, informatics.

• Utilizes excellent communication and interpersonal skills.

Basic Qualifications:

• Bachelors Degree

  • 7+ years of academic and / or industry experience

Or

• Masters Degree

  • 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 2+ of academic and / or industry experience

Preferred Qualifications:

• PhD with 2-4 years of experience.

• Experience and track record in immuno-oncology, immunology, or biologics drug discovery.

• Good understanding of vascular, stromal biology or T cell biology

• Experienced in the design, development and optimization of high-throughput cell-based assays for TCE activity.

• Proficient with primary cell culture and cancer cell line culture.

• Experience with expression modulation tools (overexpression, CRISPRs, RNAi, etc.).

• Extensive knowledge of flow cytometry (BD, Cytek Aurora, iQue).

• Experience with automation systems (TECAN, Integra, etc.).

• Experience with imaging platforms (Incucyte, Opera Phenix etc.).

• Familiar with data mining with published data platforms (DepMap, TCGA, GTEx, GEO, etc.)

• Strong problem-solving skills and understanding of relevant scientific principles.

• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.

• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.

• Understand basics to use generative AI to accelerate workflow. Knowledge in scientific coding languages (R, python, etc.) preferred.

• Strong publication record.

#LI-Onsite

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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