Scientist, Protein Production and Screening

Scientist, Protein Production and Screening

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why weve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space.

The US Structural Biology Center of Excellence (CoE) at GSK, a new joint Vaccines and Pharma Center, will be established in Cambridge, MA in 2025. The mission of the CoE is to apply the full range of structural biology, protein biochemistry, and computational tools to design vaccine antigens, RNAs, delivery systems, and formulations for vaccines as well as to design antibodies, biologics, and small molecules.

Were looking for a passionate and highly motivated scientist to join the CoE. As a crucial member of our team you will deploy your scientific knowledge in recombinant protein production from mammalian, bacterial and/or insect expression systems. We are eager to see your contributions to our candidate screening platform to increase throughput and improve the depth of data available. The position will require active collaboration with diverse team to work together and address key challenges.

You will be expected to maintain our laboratory environment and introduce new methods/protocols related to your specific area of expertise. Your time-management and organization skills will be highly valued. This position offers you the opportunity to actively contribute to multiple pipeline projects simultaneously and directly impact the progression of our preclinical medicine and vaccine candidates. You will need to anticipate problems, proactively seek solutions, and balance competing priorities to be successful. This role interacts directly with both upstream and downstream counterparts to enable smooth communication and hand-off of materials. You will also have the opportunity to interact with scientists based in other centers and countries, ensuring that you can access the most up-to-date knowledge and capabilities to efficiently fulfill your missions.

Key Responsibilities:

• Propose, implement, maintain, and deliver existing and/or new capabilities for the high-throughput, small-scale recombinant protein production.
• Propose and implement lab automation solutions to enable rapid screening and data presentation to drive project decisions.
• Collaborate with the protein expression, protein purification, molecular design, biophysics, and structural biology teams to ensure the correct prioritization of samples.
• Deliver high quality data with appropriate control experiments and documentation
• Interpret the results of experiments and update protocols accordingly.
• Keep current with the latest developments and techniques in the field.
• Ensuring safety procedures and regulations are followed in the laboratory.
• Present research findings and updates in internal reports, project meetings, and external scientific meetings when appropriate.

Basic Qualifications:

• BSc or MSc in protein biochemistry, cell biology, biology, molecular biology or related field.
• BS and 4+, or MSc and 2+ years hand-on experience, preferably in an industrial research environment, national lab and/or other protein production core facility.
• One or more years of experience with lab automation techniques including small scale protein expression, small scale protein purification, analytical techniques in 96 and/384 well plates.
• One or more years of experience purifying protein from mammalian cell culture including HEK293 and/or CHO cell lines.
• One or more years of experience in the operation and maintenance of AKTA systems.

Preferred Qualifications:

• PhD in protein biochemistry, cell biology, biology, molecular biology or related field
• Hands-on experience with a lab automation solution, i.e. Tecan, Hamilton, and/or Echo

• Experience with the purification of proteins from additional protein expression systems including bacterial, insect and/or yeast.
• Familiarity with buffer exchange, TFF, and related process techniques.
• Ability to further characterize purified material for endotoxin contamination and/or bioburden.
• Ability to further characterization purified material using biophysical techniques including HPLC, nanoDSF, BLI, SPR and/or mass photometry.

• Excellent oral and written communication skills with a fluency in English.

• Able to efficiently manage uncertainty, changes in priority and timeline restrictions.
• Excellent problem-solving skills and the ability to troubleshoot technical issues.
• Demonstrated ability to work independently and as part of a diverse team.
• Demonstrated ability to manage competing priorities and stakeholders.
• Strong communication skills.

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Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose to unite science, technology and talent to get ahead of disease together so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, its also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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