Assistant Research Scientist

Objective

The Assistant Research Scientist (ARS) is to investigate targeted alpha-emitter therapy in support of development of novel radiopharmaceuticals. The ARS is responsible for designing and conducting non-clinical studies to evaluate the efficacy and safety of novel radiopharmaceuticals. The ARS is also responsible for conducting in vitro and in vivo experiments to optimize radiopharmaceutical drug molecules. The ARS reports to the Senior Principal Scientist and works collaboratively with colleagues from other teams as well as from other departments on transitioning pipelines from preclinical stage to clinical stage.

Essential Functions

• Maintain logs, lab notebooks, and other documentation with diligence and recognizes that data integrity is of upmost importance through all aspects of the process from the discovery stage of development through commercialization of products.
• Design and conduct experiments to support the discovery, development and characterization of theranostic radiopharmaceuticals independently upon training.
• Perform radiochemical synthesis for in vitro assays, including ligand binding and affinity assays, and stability evaluation.
• Perform in vivo animal studies (mostly using mouse model) to evaluate the PK/PD features, therapeutic efficacy and toxicity of radiopharmaceuticals.
• Conduct cellular and molecular studies, including ELISA, DNA and RNA isolation, gel electrophoresis, Western Blot, RT-PCR, real time PCR, flow cytometry, and IHC.
• Apply routine aseptic skills for cell culture and tumor inoculation.
• Analyze experiment results and generate high-quality reports to support IND applications.

Qualifications

SAFETY - PRIORITY 1: The ARS is experienced, skilled, understands and provides leadership in supporting and promoting safety as the most important part of all experimental design and in carrying out experiments throughout the process of radiopharmaceutical development, from preclinical to clinical use of products and candidate products.

RADIOPHARMACEUTICAL SCIENCE: While perhaps specializing in key aspects of radiopharmaceutical development, at the highest level of professionalism, the ARS is an experienced-skilled professional who understands radiopharmaceutical sciences in cancer therapy and holds this profession in high esteem.

Education / Experience

• Master or PhD degree in Pharmacology, Pharmaceutical Sciences, Chemistry, Biochemistry Bioengineering, Biomedical Engineering, Veterinary Medicine or related field.
• PhD degree or master's degree with 1-5 years of working experience in research labs.
• 1-3 years' working experience in health or cancer-related fields.
• 1-3 years' hands-on experience in developing and using murine models
• Experience with biochemical or molecular/cellular biology, such as cell-based assays, enzymatic assays, aseptic cell culture techniques, ELISA, qPCR, flow, IHC, etc.
• Experience with routine analytical equipment such as HPLC, TLC.
• Experience with in vivo studies using laboratory animal models.
• Experience with radioisotopes (preferred/recommended)
• Experience with wet chemistry, biology, cell culture.
• Experience with histopathological sample processing skills, slides sectioning, staining, etc.

Knowledge / Skill / Ability

• Has multidisciplinary training and knowledge of cancer biology, cellular and molecular biology, pharmaceuticals sciences, pharmacology, toxicology, radiochemistry, chemistry, analytical chemistry, and nuclear medicine, etc.
• Experience with GraphPad Prism, Microsoft Office, writing and following SOPs, data analysis, statistical analysis, oral presentation
• Full range of motion and ability to use both hands mandated by machinery. High degree of manual dexterity.
• Comfort with various computer operating systems and laboratory operational platforms.
• Ability to maintain focus on a complex task for 4-6 hours at a time.
• Keep record of peer-reviewed publications as 1st and/or co-author in numerous publications.
• Must be able to regularly lift 10 lb. weights, occasional lifting of up to 50 lbs.
• Good communications, interpersonal and collaboration skills, and ability to interact professionally with a wide range of individuals and organizations, internal and external.
• Ability to work independently with minimal direction, and drive deliverables through to completion by deadlines provided.
• Highly organized with strong attention to detail and commitment to high quality work.
• Good interpersonal skills and ability to communicate information in a timely manner.
• The ability to work within a corporate culture in which enthusiasm, respect, integrity, and teamwork are expected to be the highest of standards.

Work Environment

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions.

• Must be willing to work in a facility producing radioactive materials and requiring all employees to participate in safety programs designed to minimize potential and/or actual exposure levels.
• Available to work outside of regular work hours, including off shift, weekend, and holiday work as business needs require.
• May be required to sit or stand for long periods of 8+ hours a day while performing duties.
• Occasional kneeling, crouching, twisting the upper body, bending, stooping, pushing, pulling, or reaching may be required.
• Must possess good hand-eye coordination; close attention to detail is required.
• Must be able to work indoors and outdoors with exposure to mechanical/moving parts, hazards including radioactive, corrosive, flammable and toxic material, dust, dirt, odors, and irritants.
• Must be willing to wear a variety of Personal Protective Equipment (PPE), including eye and hearing protection, as needed.
• Willingness to complete safety training within allotted timeframes, and work in a team-based environment.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities, and activities may change at any time with or without notice.

Perspective Therapeutics provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

For information on Perspective Therapeutics, visit our website at: www.perspectivetherapeutics.com.