Scientist/Senior Scientist, Computational Drug Design

The Position

Arrowhead Pharmaceuticals is seeking a talented and motivated Scientist or Senior Scientist in Computational Drug Design to join our interdisciplinary drug discovery team. This role is ideal for a creative, independent thinker with strong technical skills in machine learning and a passion for applying computational approaches to advance next-generation therapeutics. The successful candidate will contribute to the design and optimization of novel antibody-siRNA conjugates using cutting-edge AI/ML methodologies.

Responsibilities

• Develop and curate large biological datasets by integrating internal and publicly available data sources.
• Design, train, and apply predictive models for antibody-siRNA conjugate drug design.
• Apply AI techniques to extract insights and generate testable biological hypotheses from model outputs.
• Monitor and critically assess emerging developments in AI/ML for therapeutic discovery.
• Communicate research findings effectively to project teams and senior stakeholders.

Requirements:

• Ph.D. in Computational Chemistry, Computational Biology, Bioinformatics, Computer Science, or a related discipline.
• Strong programming skills in Python (or equivalent), with experience using common scientific libraries and proficiency in UNIX-based environments.
• Practical experience with deep learning frameworks such as TensorFlow, PyTorch, or JAX.
• Proven experience applying machine learning to solve complex biological or chemical problems.
• Hands-on experience in RNA and/or protein structure prediction and relevant in silico design tools.
• A strong track record of scientific impact as evidenced by publications, conference presentations, or patents.
• Flexible and adaptable to changing research priorities and project needs.