Senior Bioinformatics Scientist - III

Senior Bioinformatics Scientist - III

Employer

Careers Integrated Resources Inc

Location

Cambridge, Massachusetts, US

Salary

Competitive

Closing date

Jul 31, 2025

Apply on website

Job Title: Senior Bioinformatics Scientist - III

Job Location: Cambridge, MA

Job Duration : 24+ Months (Possibilities of Extension)

Pay rate: $100.50/Hour on W2

Job Description:

The Precision Genetics group within the Data and Genome Sciences Department is seeking a skilled Contractor to join our Computational Precision Immunology team. We focus on multi-modal and multi-scale data analyses to drive innovative research in precision genetics.

Key Responsibilities:

Data Ingestion:

Query external databases such as PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, and Ensembl to acquire relevant multi-omics datasets.

RNA-seq Analysis:

Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using tools like FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, and LeafCutter.

Multi-Omics Analysis:

Analyze diverse molecular data types, including spatial transcriptomics (Slide-seq, MERFISH, squidpy) and proteomics (OLINK, mass spectrometry-based approaches).

Data Integration:

Integrate multi-omics datasets including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.

Documentation:

Prepare detailed documentation of analysis methods and results in a timely manner.

Required Qualifications:

Ph.D. in Computational Biology or a related field.

5+ years of experience in multi-omics analysis.

Strong understanding of statistical methods and multi-omics data analysis/integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).

Proficiency in R, Python, and Bash; ability to implement best practices for reproducible data analyses.

Experience with high-performance computing (HPC) systems and AWS Cloud Computing (IAM, S3 buckets).

Collaborative, self-motivated, strong work ethic, ability to manage multiple priorities in a dynamic environment.

Excellent written and verbal communication skills.