Senior Research Associate

  • Nautilus Biotechnology Inc.
  • San Carlos, California
  • Full Time
Senior Research Associate

Location

San Carlos

Employment Type

Full time

Location Type

On-site

Department

Affinity Reagent Development

Compensation

$86K - $127K Offers Equity

The hiring pay range for this position is based on skills, education, and experience relevant to the role. New hires are typically hired into the low to midpoint of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Pay ranges are adjusted based on cost of labor in each respective geographical market. Your recruiter can share more about the specific pay range for your location during the hiring process.

Benefits include medical, vision, and dental insurance, group and supplemental life insurance, 401k retirement plan, responsible (unlimited) paid time off, parental leave, and more. Other components of total compensation include a competitive options grant at the time of hire (with potential for additional grants).

Overview

Application

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are hiring for a Senior Research Associate to join our growing team. This role is within the Core Lab team and focuses on ensuring internal and external customer success by supporting their research and development initiatives. The person in the role will be responsible for execution of proteome and proteoform detection workflows, customer sample processing, and assay transfer on the Nautilus single-molecule proteomics platform, while collaborating cross-functionally to advance platform capabilities and support operational excellence.

Responsibilities

Responsible for receiving and documenting customer samples

Process and analyze customer samples routinely on the Nautilus single molecule proteomics platform

Perform affinity reagent characterization against complex targets on the Nautilus platform

Implement assay transfer from R D to Service Lab

Implement characterization of affinity reagents developed in house

Support daily operations of the team and provide technical input to troubleshoot failures

Oversee and execute multiple projects in parallel to successfully meet team goals

Contribute to authoring Standard Operating Procedures, Standard Test Procedures, Master Batch Records, and other documents

Qualifications

BS+4 years industry experience or equivalent in biochemistry, molecular biology, genetics, or related field or MS+2 years industry experience

Prior experience with complex protein sample types such as cell, tissue or plasma lysates strongly preferred

Experience in handling complex workflows on different instrument types in preferred strongly

Previous experience with sample accessioning and LIMS/ELN workflow systems is preferred

Previous experience with BLI, SPR based antibody or protein characterization is a plus

Ability to meet project timelines and deliverables consistently

Excellent written and oral communication skills

Flexibility and ability to learn new technologies quickly and respond to changing priorities and project directions

Nautilus Team Culture

We are determined to do whatever it takes to get our platform into the hands of researchers who will use it to upend the status quo in basic research and healthcare.

We work on cross functional teams, wear many hats, take risks to work through uncertainty, enjoy working collaboratively on challenging problems, and celebrate one another's victories.

We go above and beyond, but also strive to provide a supportive atmosphere of colleagues who are willing to lend a helping hand and make working at Nautilus not only fulfilling in its end goals, but enjoyable on a day-to-day basis.
Job ID: 487377859
Originally Posted on: 7/30/2025

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