Senior Scientist/Principal Scientist, Computational Immunology

Janux is seeking a highly motivated and skilled Senior or Principal Scientist in Immunology to join our dynamic R&D team. This individual will play a critical role in advancing our understanding of how Janux's drug candidates modulate immune responses, with a particular focus on T cell biology. The ideal candidate will be an expert in RNA sequencing workflows-from wet lab execution to computational analysis-and will thrive in a collaborative, fast-paced biotech environment.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

• Analyze large-scale RNA-seq datasets to uncover:
• Transcriptional changes in immune cells
• Mechanistic insights into drug activity
• Biomarkers of response or resistance
• Collaborate cross-functionally with protein engineering, protein sciences, and translational/pharmacology teams to interpret data and guide decision-making.
• Present findings to internal stakeholders and contribute to scientific and regulatory documents.
• Design and execute in vitro immunological assays including:
• Primary T cell culture and stimulation
• Flow cytometry and cell staining
• Drug screening and functional assays
• Prepare immune cell samples for RNA sequencing, including:
• Cell isolation and processing
• Library preparation and sequencing run setup
• Other duties as deemed necessary

REQUIRED EDUCATION, EXPERIENCE, SKILLS, AND ABILITIES

• Ph.D. in Bioinformatics, Computational Biology, Immunology, Molecular Biology, or a related field with 4+ years (Senior Scientist) or 6+ years (Principal Scientist) of relevant experience in academia or industry.
• Deep expertise in T cell biology and immunological assay development.
• Hands-on experience with RNA sequencing workflows, including sample prep, sequencing instrumentation, and data analysis.
• Proficiency in bioinformatics tools and pipelines for transcriptomic analysis (e.g., R, Python, Seurat, DESeq2, Loupe).
• Strong communication skills and a collaborative mindset.

$135,000 - $182,000 a year

In addition to a competitive base salary ranging from $135,000 to $158,000 for a Senior Scientist, and $158,000 to $182,000 for a Principal Scientist, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available.

Please note that the hourly rate range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, and internal equity.

Job Type: Full-time

Benefits:

• 401K
• Medical insurance
• Dental insurance
• Vision insurance
• Supplemental disability insurance plans
• Flexible schedule
• Life insurance
• Flexible vacation
• Sick time
• Incentive stock option plan
• Relocation assistance

Schedule:

• Monday to Friday

Work authorization:

• United States (Required)

Additional Compensation:

• Annual targeted bonus %

Work Location:

• On site (San Diego, CA)

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect theinterests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.