Analytical Development Research Associate - Testing, Operation and Automation

Job Description

General Summary:

The Analytical Development Research Associate performs a variety of well-dened support functions and performs analytical procedures as outlined by their supervisor. The Analytical Development Research Associate will support the goals and timelines for the analytical development team through timely completion of assay development projects, demonstrate excellent documentation skills and will be responsible for specic lab or Group/Department service functions.

Key Duties and Responsibilities:

• Support routine maintenance of stem cells, primary cells and other mammalian cell lines in different culture formats (2D and 3D cell culture).

• Support routine analytical testing for in-process, release and characterization assays for flow cytometry, cell-based potency assays, cell count, and cell viability assays using automation systems or manual mode to support cell and gene process development and process characterization

• Support collecting samples and distribution to various stakeholders of Cell Culture time course samples.

• Utilize automated liquid handling platforms like Hamilton, TECAN, Janus etc to carry out routine cell culture activities and assays.

• Involved in the development of novel automated analytical assays including but not limited to measuring cell viability and proliferation using automated fluorescent high content screening tools.

• Involved in developing real time monitoring assay to develop model for cell analytics using LumaCyte Radiance Platform.

• Update the power BI dashboard for 3D size, Cell viability and cell count on a routine basis.

• Maintain meticulous records of experimental workflows, protocols and results and help assist in the generation of documentation to support experiments

• Compile information obtained through experimental work into presentations and reports.

• Collaborate cross functionally across different teams (PD, AD and other external partners) to ensure timely delivery of data and information.

• Occasional weekend and holiday support will be needed for this role

Knowledge and Skills:

• Mammalian cell culture methods for different types of stem cells including hematopoietic stem cells , IPSCs, primary cells and cell lines with proper knowledge of aseptic techniques.

• Experience working with both 2D and 3D culture of mammalian cells and sample preparation for 3D culture for cell based assays.

• Experience operation complex automation equipment including liquid handlers like Hamilton, Tecan, JANUS etc. and other high content screening tools like Celigo, CellVista, Cytation etc

• Experience working with fluorescence cell culture assays including cell count and cell viability, immunofluorescence, imaging assays.

• Effective inter-personal and communication skills.

• Ability to work with urgency and planning to ensure delivery of high-quality data.

• Is a creative, curious individual who can pick up laboratory and other skills quickly.

• Is able to effectively manage their time to ensure that activities with competing timelines can be done effectively and on time.

• Team player, innovative, collaborative, and initiative

Education and Experience:

• Bachelor's degree (or equivalent degree) and 1-4 years of relevant employment experience

• Typically requires 2 years experience in an assay development environment

• Hands on experience with 1-2 assay platforms used for characterization and release assays

Pay Range:

$63,100 - $94,600

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ...