Senior Scientist 1, Biophysical Characterization

Who We Are At BioMarin , we are driven by a singular mission: to transform lives through bold science. As a global biotechnology leader, we specialize in translating genetic discoveries into groundbreaking therapies that redefine the future of human health. Since 1997, weve leveraged our deep expertise in genetics and molecular biology to develop innovative treatments for rare and serious genetic conditions. Our approach is rooted in scientific rigor, a passion for solving complex problems, and a commitment to delivering meaningful advances for patients with unmet medical needs. We bring together top-tier talentscientists, innovators, and problem-solversand foster a collaborative environment where bold ideas thrive. This has enabled us to build a diverse pipeline of commercial, clinical, and preclinical candidates with the potential to be first-in-class or best-in-class therapies. About Worldwide Research and Development (WWRD) WWRD spans the full spectrum of drug developmentfrom early discovery through post-market clinical research. Our integrated teams work across disciplines to develop transformative therapies that make a real difference in the lives of patients with genetic diseases. Position: Senior Scientist, Biophysical Characterization Location: San Rafael, CA
Department: Research & Early Development Therapeutic Modality Team We are seeking a Senior Scientist in Biophysical Characterization to help shape the future of next-generation biologics, bioconjugates, and non-viral nanoparticle delivery systems. This is a unique opportunity for a scientifically rigorous, forward-thinking biophysicist to drive innovation at the intersection of discovery and translational science. As a key member of the Therapeutic Modality Team, you will lead the development of advanced biophysical workflows, design custom assays to elucidate mechanisms of action, and serve as a strategic analytical expert. Your insights will directly influence candidate selection, manufacturability, and regulatory strategyaccelerating the journey from bench to bedside. Key Responsibilities

• Strategic Leadership in Biophysical Characterization
  Design and lead scalable, phase-appropriate biophysical strategies for complex therapeutic modalities aligned with program goals.
• Assay Development & Innovation
  Develop and validate robust assays to assess higher-order structure, aggregation, stability, and target engagement.
• Cross-Functional Collaboration
  Partner with discovery, process development, formulation, and regulatory teams to integrate biophysical insights into decision-making.
• Technology Transfer & External Partnerships
  Lead assay transfer to Analytical Sciences and external partners (CROs/CDMOs), including preparation of comprehensive tech transfer packages.
• Scientific Innovation & External Engagement
  Stay at the forefront of emerging technologies. Collaborate with academic and industry partners to evaluate novel platforms and delivery strategies.
• Regulatory Support
  Generate high-quality data packages for regulatory submissions (e.g., INDs) and ensure compliance with internal and global standards.
• Mentorship & Culture Building
  Mentor junior scientists and contribute to a culture of scientific excellence, innovation, and continuous learning.

Qualifications Education:

• Ph.D. in Biophysics, Biochemistry, or a related field
• M.S. or B.S. candidates with exceptional experience will also be considered

Experience:

• Ph.D. with 6+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant industry experience
• Expertise in characterizing protein-based biologics, bioconjugates, and/or nanoparticle delivery systems
• Proven track record supporting regulatory submissions with complex molecule characterization
• Hands-on experience with techniques such as DLS, FFF-MALS, SEC-MALS, CAD-HPLC, AUC, DSC, CD, FTIR, ITC, SPR
• Familiarity with high-throughput screening, automation, and AI-driven data analysis is a plus

Core Competencies

• Strong problem-solving and critical thinking skills
• Excellent scientific writing and communication abilities
• Proven leadership in cross-functional, matrixed environments
• Demonstrated initiative in adopting and implementing innovative technologies

Preferred Qualifications

• Experience developing therapeutic release assays across development stages
• Successful assay technology transfer to CROs/CDMOs
• Familiarity with regulatory submissions and health authority interactions
• Strong record of innovation (e.g., patents, peer-reviewed publications)

Additional Information This job description is intended to convey essential responsibilities and qualifications. It is not an exhaustive list of all duties or expectations. Equal Opportunity Employer BioMarin is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability.