Principal Scientist, Discovery Biology, Oncology

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Position Summary:

This exciting role offers the opportunity to shape the next generation of Cancer Immunology and T cell engager therapies to transform patient outcomes. We are seeking an innovative scientist with leadership potential to advance drug discovery programs in Cancer Immunology from target nomination to IND filing. They will join the Discovery Biology Team within the Oncology Thematic Research Center at Bristol Myers Squibb in Seattle, WA. The qualified candidate should be a highly motivated, independent, interactive, and creative scientist capable of working within and leading cross-functional teams to advance drug discovery programs.

The successful candidate will be expected to lead matrixed teams to advance both our T cell engager strategy and therapeutic project teams, from early target validation through IND filing. They will also contribute hands-on at the bench through in vitro biology work. This work includes developing and validating assays such as flow cytometry, mid-scale screening, T cell bioassay, molecular biology, and other approaches that will enable drug candidate discovery and advance our understanding of T cell engager mechanisms of action. Additionally, this individual will contribute to similar efforts related to the nomination and development of novel Cancer Immunology therapeutics that target immune suppressive and other cell populations in the tumor microenvironment. In addition to leading candidate discovery and characterization efforts, the successful candidate will work with bioinformaticians and translational research scientists to design and execute work supporting patient and indication selection as well as the development of a biomarker plan.

Position Responsibilities:

This role offers the opportunity to drive scientific innovation and shape the strategic direction of novel immunotherapy development at BMS in a highly collaborative environment that is guided by strong science.

In the role as a Principal Scientist within Discovery Biology, the ideal candidate will:

• Lead highly matrixed discovery strategy and project teams (from target concept to IND) that may influence portfolio decisions and have cross-functional impact across BMS

• Coordinate and participate in activities of a biology team to support in vitro experimentation

• Leverage internal screening and reverse translational datasets along with the scientific literature to propose and develop novel approaches for Cancer Immunology and T cell engager therapies

• Collaborate with functional area leads (e.g. in vivo pharmacology, translational biology, DMPK, informatics, and predictive science) to define priorities, assess risks, and drive project progression

• Apply deep technical knowledge to validate and execute on in vitro assays that elucidate drug mechanisms of action and optimize therapeutic profiles

• Interpret complex biological data to inform decision-making and guide lead optimization

• Communicate scientific findings and strategic recommendations effectively across the broader BMS enterprise

• Utilize excellent communication and interpersonal skills to foster collaboration across multidisciplinary teams

Experience = We are seeking a motivated scientist who combines deep immunology expertise with a passion for innovation. You thrive in a collaborative environment, enjoy solving complex biological problems, and are driven by the opportunity to make a meaningful impact on patients lives.

Basic Qualifications:

• Bachelors Degree

  • 8+ years of academic and / or industry experience

Or

• Masters Degree

  • 6+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 4+ years of academic and / or industry experience

Preferred Qualifications

• Ph.D. or equivalent advanced degree in the Life Sciences

  • 4+ years of academic and / or industry experience

• Deep experience in the discovery and development of complex biologics, such as bispecific antibodies, ADCs, or immune cell engagers

• Hands-on experience contributing to IND-enabling studies, including data generation, interpretation, and document writing

• In depth understanding of immunology, with demonstrated expertise in T cell-based in vitro assays

• Demonstrated scientific curiosity, resilience, and a strong drive to solve complex biological problems through innovative thinking

• Strong leadership potential with a track record of mentoring or guiding scientific teams

• Excellent organizational skills with the ability to manage and prioritize multiple projects across internal and external collaborators

• Demonstrated ability to analyze, interpret, and clearly communicate complex scientific data

• Outstanding oral and written communication skills tailored to both scientific and cross-functional audiences

• Strong problem-solving skills and the ability to apply scientific principles to address complex research challenges

The starting compensation for this job is a range from $149,390 - $181,000, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

#LI-Onsite

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement.

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